INT242471

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2008
Negated 3
Speculated 1
Reported most in Body
Documents 1
Total Number 45
Disease Relevance 54.25
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ciapin1) nucleus (Ciapin1) cytoplasm (Ciapin1)
Anatomy Link Frequency
liver 6
Chang liver 4
Ciapin1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 45 96.88 Very High Very High Very High
cytokine 45 86.44 High High
palliative 45 62.52 Quite High
adenocard 45 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 1080 100.00 Very High Very High Very High
Targeted Disruption 315 99.88 Very High Very High Very High
Hepatocellular Cancer 3510 99.84 Very High Very High Very High
Cancer 2565 99.68 Very High Very High Very High
Apoptosis 1665 99.62 Very High Very High Very High
Hepatitis 270 99.44 Very High Very High Very High
Stomach Cancer 45 95.12 Very High Very High Very High
Sprains And Strains 45 92.88 High High
Hematological Disease 180 92.40 High High
Death 315 90.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data indicate that compared with the Chang liver cells, the expression of CIAPIN1 was significantly increased in all four HCC cell lines (Figure 1C).


Gene_expression (expression) of CIAPIN1 in Chang liver associated with hepatocellular cancer
1) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.96 Pain Relevance 0
In this study, we detected that CIAPIN1 expression is elevated in majority HCC patient samples and HCC cell lines, and consequently, we hypothesized that overexpression of CIAPIN1 may be associated with hepatocarcinogenesis and knock down of CIAPIN1 may inhibit tumorigenic growth of HCC in which CIAPIN1 is overexpressed.
Gene_expression (expression) of CIAPIN1 associated with targeted disruption and hepatocellular cancer
2) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.31 Pain Relevance 0
In addition to showing the successful use of AdSiRNA in silencing CIAPIN1 overexpressed in HCC cells, our results also indicate that CIAPIN1 might serve as a novel promising therapeutic target for HCCs.
Gene_expression (overexpressed) of CIAPIN1 associated with hepatocellular cancer
3) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.75 Pain Relevance 0
In this study, we detected that CIAPIN1 expression is elevated in majority HCC patient samples and HCC cell lines, and consequently, we hypothesized that overexpression of CIAPIN1 may be associated with hepatocarcinogenesis and knock down of CIAPIN1 may inhibit tumorigenic growth of HCC in which CIAPIN1 is overexpressed.
Gene_expression (overexpression) of CIAPIN1 associated with targeted disruption and hepatocellular cancer
4) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.01 Pain Relevance 0
Tumorigenesis is associated with multiple factors and CIAPIN1 overexpression may be an important factor in HCC; thus, we hypothesize that knock down of CIAPIN1 expression may inhibit the growth of HCC in which CIAPIN1 is overexpressed.
Gene_expression (overexpressed) of CIAPIN1 associated with targeted disruption and hepatocellular cancer
5) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.11 Pain Relevance 0
The CIAPIN1 expression in the HCC samples with the hepatitis B virus and/or hepatitis C virus infection was similar to that in the uninfected ones (33 versus 25%, P > 0.05), and we did not find any relationship between the hepatitis B virus and/or hepatitis C virus infection with the CIAPIN1 expression (P > 0.05).
Gene_expression (expression) of CIAPIN1 associated with hepatocellular cancer, infection and hepatitis
6) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.81 Pain Relevance 0
Our studies here were designed to test whether the more advantageous AdSiRNA can be applied to target HCC cells selectively with overexpression of a recently reported antiapoptosis gene, CIAPIN1, which is overexpressed in a higher percentage of HCC patients.
Gene_expression (overexpressed) of CIAPIN1 associated with hepatocellular cancer
7) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.03 Pain Relevance 0.04
There is no induced apoptosis observed in normal Chang liver, which is absent from CIAPIN1 expression, and this specificity should increase the therapeutic index of RNAi-based therapies.
Neg (absent) Gene_expression (expression) of CIAPIN1 in Chang liver associated with apoptosis
8) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.96 Pain Relevance 0.04
Our studies here were designed to test whether the more advantageous AdSiRNA can be applied to target HCC cells selectively with overexpression of a recently reported antiapoptosis gene, CIAPIN1, which is overexpressed in a higher percentage of HCC patients.
Gene_expression (overexpression) of CIAPIN1 associated with hepatocellular cancer
9) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.04 Pain Relevance 0.04
The inhibitory effect of the AdSiCIAPIN1 was shown to be specific because a control AdSiGFP had no effect on CIAPIN1 expression level.
Gene_expression (expression) of CIAPIN1
10) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.62 Pain Relevance 0
Therefore, our studies suggest that knock down of CIAPIN1 by adenovirus-delivered siRNA may be a potential therapeutic strategy in the treatment of HCC in which CIAPIN1 is overexpressed.


Gene_expression (overexpressed) of CIAPIN1 associated with targeted disruption and hepatocellular cancer
11) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.13 Pain Relevance 0
To test if apoptosis can be triggered in normal cells that do not overexpress CIAPIN1, we also infected normal Chang liver with AdSiRNA.
Neg (not) Gene_expression (overexpress) of CIAPIN1 in Chang liver associated with apoptosis
12) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.90 Pain Relevance 0
As shown in Figure 2A, the suppression of CIAPIN1 expression was detected as early as 48 h after infection, and the suppression was up to 80% in the cells infected with AdSiCIAPIN1 at 96 h.
Gene_expression (expression) of CIAPIN1 associated with infection
13) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.70 Pain Relevance 0
It was clear that the tumor tissue specimens had a drastic increase of CIAPIN1 expression as compared with the normal liver tissue, which was consistent with the level of CIAPIN1 protein expression determined by immunohistochemical staining.
Gene_expression (expression) of CIAPIN1 in liver associated with cancer
14) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.37 Pain Relevance 0
In this study, we reported that CIAPIN1 is highly expressed in HCC as compared with non-tumor hepatic tissue (P < 0.05).
Gene_expression (expressed) of CIAPIN1 associated with cancer and hepatocellular cancer
15) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Abstract Doc Link PMC2516489 Disease Relevance 1.24 Pain Relevance 0.04
CIAPIN1 expression in four HCC cell lines was examined to assess the biological activities by western blot analysis.
Gene_expression (expression) of CIAPIN1 associated with hepatocellular cancer
16) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.09 Pain Relevance 0
To further confirm these observations, western blot assay was done using four paired human normal liver tissues and their tumor tissue specimens with known levels of CIAPIN1 expression by immunohistochemical staining (Figure 1B).
Gene_expression (expression) of CIAPIN1 in liver associated with cancer
17) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.56 Pain Relevance 0
In this study, we detected that CIAPIN1 expression is elevated in majority HCC patient samples and HCC cell lines, and consequently, we hypothesized that overexpression of CIAPIN1 may be associated with hepatocarcinogenesis and knock down of CIAPIN1 may inhibit tumorigenic growth of HCC in which CIAPIN1 is overexpressed.
Gene_expression (overexpressed) of CIAPIN1 associated with targeted disruption and hepatocellular cancer
18) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.97 Pain Relevance 0
CIAPIN1 expression was classified as negative, weak and strong in 13 (29.6%), 10 (22.7%) and 21 (47.7%) patients, respectively (Table I).
Gene_expression (expression) of CIAPIN1
19) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.81 Pain Relevance 0
This blockage of S-phase entry combined with the enhanced cyclinD1 and decreased P27 expression in SMMC-7721 cells conversely substantiated the effect of CIAPIN1 overexpression on HCC, by regulating cyclinD1 and P27 to activate expression of genes necessary for entering into the S phase.
Gene_expression (overexpression) of CIAPIN1 associated with hepatocellular cancer
20) Confidence 0.78 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.05 Pain Relevance 0.04

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