INT2425

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Context Info
Confidence 0.58
First Reported 1979
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 1.77
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ret)
Anatomy Link Frequency
EPI 4
adipocyte 2
brain 1
Ret (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 2 98.72 Very High Very High Very High
noradrenaline 5 98.12 Very High Very High Very High
Dopamine 5 97.76 Very High Very High Very High
Spinal cord 2 93.48 High High
Substantia nigra 7 93.36 High High
antagonist 2 82.28 Quite High
orphanin 4 75.00 Quite High
monoamine 1 75.00 Quite High
Clonidine 1 65.44 Quite High
Opioid 1 36.68 Quite Low
Disease Link Frequency Relevance Heat
Obesity 138 93.20 High High
Hyperlipidemia 42 92.72 High High
Disorder Of Lipid Metabolism 162 81.88 Quite High
Weight Gain 36 66.52 Quite High
Dyslipidemia /

Combined Dyslipidemia

60 65.04 Quite High
Body Weight 66 62.24 Quite High
Atherosclerosis 18 56.08 Quite High
Metabolic Disorder 12 54.40 Quite High
Peripheral Arterial Disease 6 50.56 Quite High
Coronary Heart Disease 42 46.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of 4-aminopyridine (4-AP) on the turnovers of 5-hydroxytryptamine, dopamine and noradrenaline in the central nervous system of rats were studied by means of amine disappearance following inhibition of tryptophan or tyrosin hydroxylase. 4-AP (3 mg/kg i.p.) did not change the utilizations of 5-hydroxytryptamine or dopamine but it markedly accelerated that of noradrenaline in the brain and in the spinal cord.
Negative_regulation (inhibition) of tyrosin hydroxylase in brain associated with dopamine, noradrenaline, central nervous system and spinal cord
1) Confidence 0.58 Published 1979 Journal J. Neural Transm. Section Abstract Doc Link 438799 Disease Relevance 0 Pain Relevance 0.53
In this study, continuous exercise of 5 consecutive days/week resulted in a significant decrease in RET and EPI adipocyte area in both diets (*), while 2 consecutive days/week exercise showed a decrease only for the hypercholesterolemic group, again indicating favorable adaptations for this exercise frequency in a hypercholesterolemic situation.
Negative_regulation (decrease) of RET in EPI
2) Confidence 0.40 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1933532 Disease Relevance 0.36 Pain Relevance 0
Some studies observing the effects of 5 consecutive days/week swimming exercise in adult male rats report significant decrease in RET and EPI adipocyte area and diameters [23,30], but no mention was made of 2 consecutive days/week exercise frequency.
Negative_regulation (decrease) of RET in adipocyte
3) Confidence 0.30 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1933532 Disease Relevance 0.11 Pain Relevance 0
Moderate continuous 5 days/week exercise significantly decreased EPI and RET relative weight in both diets when compared to respective sedentary groups on the same diet, while 2 days/week exercise (TC2) presented a decreased in RET and EPI when compared to sedentary control group (C), only in a cholesterol-rich diet.
Negative_regulation (decreased) of RET in EPI
4) Confidence 0.30 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1933532 Disease Relevance 0.39 Pain Relevance 0
We further observed that TH5 (°) group experienced a significant reduction in RET adipocyte area compared to TC5 group.
Negative_regulation (reduction) of RET in adipocyte
5) Confidence 0.30 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1933532 Disease Relevance 0.17 Pain Relevance 0
Adipocyte area results generally showed that continuous training exercise (both 5 and 2 days/week) can promote a significant decrease in RET and EPI adipocyte area, mainly in hypercholesterolemic situations; however, the effects of 5 consecutive days/week training were more pronounced compared to those of 2 days/week training (+) (Table 4).


Negative_regulation (decrease) of RET in EPI
6) Confidence 0.30 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1933532 Disease Relevance 0.11 Pain Relevance 0
In this study we found that even in normal cholesterol chow diet or cholesterol-rich diet situations, both exercise frequencies were effective in significantly decreasing EPI and RET relative weights, when compared to the sedentary groups.
Negative_regulation (decreasing) of RET in EPI
7) Confidence 0.29 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1933532 Disease Relevance 0.51 Pain Relevance 0
The inhibitory role played by endogenous N/OFQ on motor activity was additionally strengthened by the finding that mice lacking the NOP receptor gene outperformed wild-type mice on the rotarod.
Negative_regulation (lacking) of NOP receptor gene
8) Confidence 0.04 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15282268 Disease Relevance 0 Pain Relevance 0.41

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