INT242520

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.49
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ret) kinase activity (Ret)
Anatomy Link Frequency
sympathetic ganglion 2
neuronal 1
sympathetic 1
Ret (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 145 96.76 Very High Very High Very High
Neuropeptide 35 84.64 Quite High
nociceptor 95 30.48 Quite Low
addiction 10 28.60 Quite Low
Calcitonin gene-related peptide 110 21.24 Low Low
Nav1.9 5 17.96 Low Low
sodium channel 15 17.68 Low Low
tetrodotoxin 15 13.68 Low Low
Action potential 5 9.28 Low Low
c fibre 85 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 330 100.00 Very High Very High Very High
Death 35 99.40 Very High Very High Very High
Sprains And Strains 30 88.88 High High
Apoptosis 40 87.28 High High
Ocular Toxicity (including Many Sub-types) 30 36.64 Quite Low
Targeted Disruption 70 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Nociception 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutational inactivation of ret leads to an almost complete loss of cholinergic markers in newborn sympathetic ganglia
Negative_regulation (inactivation) of ret in sympathetic
1) Confidence 0.35 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.12 Pain Relevance 0.04
Mutational inactivation of the ret gene affects sympathetic ganglion cell number in a complex manner by altering precursor migration, proliferation and cell survival
Negative_regulation (inactivation) of ret in sympathetic ganglion associated with ganglion cysts
2) Confidence 0.35 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.68 Pain Relevance 0
In ret mutant mice, sympathetic ganglion cell number is reduced even at E11.5 by 30% as compared with wildtype.
Negative_regulation (reduced) of ret in sympathetic ganglion associated with ganglion cysts
3) Confidence 0.30 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.41 Pain Relevance 0.04
In addition, GFRalpha1- and GFRalpha2-expressing cells are reduced at P2 and P10 in ret mutants by 60% and 25%, respectively (Luo et al. 2007).The results suggest that NGF signalling controls the initial expression of GFRalpha1 and GFRalpha2, whereas ret autoregulates their levels at later stages.
Negative_regulation (reduced) of ret associated with nerve growth factor
4) Confidence 0.30 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.18
The increase in pyknotic cells in SCG and STG of newborn animals and at E16.5 in STG shows that cell death contributes to neuronal cell loss in ret mutant mice during the third week of embryonic development to birth (Enomoto et al. 2001).
Negative_regulation (loss) of ret in neuronal associated with ganglion cysts and death
5) Confidence 0.30 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 1.28 Pain Relevance 0

General Comments

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