INT242528

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 1.17
Pain Relevance 5.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra1)
Anatomy Link Frequency
neurons 4
embryos 1
glial cell 1
sympathetic 1
midbrain 1
Gfra1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 285 100.00 Very High Very High Very High
trigeminal ganglion 15 99.62 Very High Very High Very High
Nerve growth factor 435 99.40 Very High Very High Very High
Dopamine 181 97.76 Very High Very High Very High
midbrain 40 95.40 Very High Very High Very High
TRP channel 105 93.28 High High
Calcitonin gene-related peptide 330 88.36 High High
ASIC 15 78.60 Quite High
Nav1.9 15 78.12 Quite High
sodium channel 45 77.84 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 990 99.64 Very High Very High Very High
Targeted Disruption 214 85.24 High High
Death 105 57.92 Quite High
INFLAMMATION 30 37.64 Quite Low
Apoptosis 120 20.52 Low Low
Ocular Toxicity (including Many Sub-types) 90 5.00 Very Low Very Low Very Low
Sprains And Strains 90 5.00 Very Low Very Low Very Low
Hyperalgesia 15 5.00 Very Low Very Low Very Low
Nociception 15 5.00 Very Low Very Low Very Low
Pain 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is a large but incomplete overlap of ret and GFRalpha expression ret expression overlaps largely with expression of GFRalpha1, GFRalpha2 and GFRalpha3.
Gene_expression (expression) of GFRalpha1
1) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.58
In P14 mice, 18% of ret-positive cells express GFRalpha1 as analysed by double ISH (Luo et al. 2007).
Gene_expression (express) of GFRalpha1
2) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.49
Of ret-positive lumbar DRG neurons, 66% express GFRalpha1 in adult rat (Kashiba et al. 2003) and 89% in adult mice (Molliver et al. 1997), as analysed by ISH on serial sections and double ISH, respectively.
Spec (analysed) Gene_expression (express) of GFRalpha1 in neurons
3) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.56
In addition, GFRalpha1- and GFRalpha2-expressing cells are reduced at P2 and P10 in ret mutants by 60% and 25%, respectively (Luo et al. 2007).The results suggest that NGF signalling controls the initial expression of GFRalpha1 and GFRalpha2, whereas ret autoregulates their levels at later stages.
Gene_expression (expression) of GFRalpha1 associated with nerve growth factor
4) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.17
Moreover, in ret mutant mice, the expression of GFRalpha1 and GFRalpha2 is reduced in DRG.
Gene_expression (expression) of GFRalpha1
5) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.33
The expression of mRNAs for GFRalpha1, GFRalpha2, GFRalpha3 and ret is dynamically regulated in mouse sympathetic ganglia during embryogenesis (Nishino et al. 1999; Enomoto et al. 2001).
Gene_expression (expression) of GFRalpha1 in sympathetic
6) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.45 Pain Relevance 0.04
Data on the coexpression of GFRalpha receptors differ between studies (Bennett et al. 1998; Kashiba et al. 2003).Expression of GFRalpha1 and GFRalpha2, but not GFRalpha3, depends on NGF, as shown in newborn NGF/Bax double-mutant mice where GFRalpha1 is undetectable and GFRalpha2 expression is strongly reduced (Luo et al. 2007).
Gene_expression (.Expression) of GFRalpha1 associated with nerve growth factor
7) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.16
In adult rats, more than half of the ret-positive DRG cells express GFRalpha1 and one third GFRalpha2.
Gene_expression (express) of GFRalpha1
8) Confidence 0.09 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.15 Pain Relevance 0.41
In contrast, GFRalpha1- and GFRalpha2-positive DRG neurons depend on both signalling pathways.
Gene_expression (neurons) of GFRalpha1 in neurons
9) Confidence 0.08 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34
In the trigeminal ganglion of mouse embryos, GFRalpha1 and GFRalpha2 mRNAs can be detected by ISH preceding ret expression (Luukko et al. 1997).
Gene_expression (detected) of GFRalpha1 in embryos associated with ganglion cysts and trigeminal ganglion
10) Confidence 0.08 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.10 Pain Relevance 0.43
GFRalpha1-expressing DRG neurons are absent in newborn NGF/Bax mutant mice and GFRalpha2 expression is strongly reduced.
Neg (absent) Gene_expression (neurons) of GFRalpha1-expressing in neurons associated with nerve growth factor
11) Confidence 0.08 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34
m

GFRalpha1 mRNA as analysed by ISH is detectable at E12.5, gradually decreases thereafter and is undetectable at P5 (Nishino et al. 1999). mRNAs for GFRalpha2 and GFRalpha3 are expressed in most SCG cells at E12.5 and subsequently become restricted to smaller subpopulations.

Gene_expression (expressed) of GFRalpha1 mRNA associated with ganglion cysts
12) Confidence 0.08 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.47 Pain Relevance 0
Data on the coexpression of GFRalpha receptors differ between studies (Bennett et al. 1998; Kashiba et al. 2003).Expression of GFRalpha1 and GFRalpha2, but not GFRalpha3, depends on NGF, as shown in newborn NGF/Bax double-mutant mice where GFRalpha1 is undetectable and GFRalpha2 expression is strongly reduced (Luo et al. 2007).
Gene_expression (undetectable) of GFRalpha1 associated with nerve growth factor
13) Confidence 0.08 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.17
The results show that ret promotes the generation of trkA-negative nociceptors and GFRalpha1- and GFRalpha2-positive DRG neuron populations.
Gene_expression (generation) of GFRalpha1 in neuron associated with nociceptor
14) Confidence 0.07 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.46
In addition, ret mutation leads to a reduction of GFRalpha1 and GFRalpha2, but not GFRalpha3, expression.
Gene_expression (expression) of GFRalpha1
15) Confidence 0.03 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.45
Expression of receptors GFR1 and c-RET for glial cell line-derived neurotrophic factor, was upregulated by SPIE.
Gene_expression (Expression) of GFR1 in glial cell
16) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.28
In addition, expression of receptors GFR1 [36] and c-RET [37] for glial cell line-derived neurotrophic factor, which is a selective neurotrophic factor for midbrain DA neurons [38], was upregulated by SPIE.
Gene_expression (expression) of GFR1 in midbrain associated with dopamine and midbrain
17) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.38

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