INT242532

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 2.38
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
neurons 16
dorsal horn 2
nucleus ambiguus 2
Chat (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 73 99.84 Very High Very High Very High
Action potential 198 99.78 Very High Very High Very High
Dorsal horn 2 96.60 Very High Very High Very High
medulla 18 95.68 Very High Very High Very High
agonist 7 94.56 High High
Inflammation 29 94.24 High High
substance P 22 71.48 Quite High
Nerve growth factor 59 60.28 Quite High
Root ganglion neuron 3 56.36 Quite High
Neuropeptide 14 31.56 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 48 99.84 Very High Very High Very High
Stress 17 98.88 Very High Very High Very High
Disease 139 97.04 Very High Very High Very High
INFLAMMATION 33 94.24 High High
Insulin Resistance 2 90.64 High High
Ganglion Cysts 137 88.60 High High
Targeted Disruption 68 86.24 High High
Diabetes Mellitus 10 83.96 Quite High
Death 24 77.92 Quite High
Injury 3 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Somatic size was similar for ChAT+ and ChAT?
Positive_regulation (for) of Gene_expression (similar) of ChAT
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
During action potential trains at 10 Hz, the normalized action potential amplitude (normalized to the first action potential) was 0.85±0.03 for ChAT+ neurons and 0.92±0.02 for ChAT?
Positive_regulation (0.03) of Gene_expression (neurons) of ChAT in neurons associated with action potential
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0.15
neurons (ChAT+ neurons were 35.3×15.8 µm; ChAT?
Positive_regulation (neurons) of Gene_expression (15.8) of ChAT in neurons
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
During action potential trains at 10 Hz, the normalized action potential amplitude (normalized to the first action potential) was 0.85±0.03 for ChAT+ neurons and 0.92±0.02 for ChAT?
Positive_regulation (for) of Gene_expression (neurons) of ChAT in neurons associated with action potential
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0.15
During action potential trains at 10 Hz, the normalized action potential amplitude (normalized to the first action potential) was 0.85±0.03 for ChAT+ neurons and 0.92±0.02 for ChAT?
Positive_regulation (for) of Gene_expression (neurons) of ChAT in neurons associated with action potential
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0.15
Somatic size was similar for ChAT+ and ChAT?
Positive_regulation (for) of Gene_expression (similar) of ChAT
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
With increasing current injections the spiking rates of ChAT+ neurons increased to a plateau frequency of ?
Positive_regulation (increased) of Gene_expression (neurons) of ChAT in neurons
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0.05
We determined whether the SCCs express ChAT and VAChT, two critical elements for synthesis and packaging of ACh, a potential transmitter.
Spec (whether) Positive_regulation (packaging) of Spec (whether) Gene_expression (express) of ChAT
8) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.08 Pain Relevance 0.07
The overlay of both channels is shown in c. d–f Magnification of the region of the nucleus ambiguus identified by high levels of ChAT expression (e).
Positive_regulation (levels) of Gene_expression (expression) of ChAT in nucleus ambiguus
9) Confidence 0.29 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691554 Disease Relevance 0 Pain Relevance 0.12
The data show that ret is required for the development of cholinergic sympathetic neurons at advanced developmental stages but not for the induction of ChAT and VAChT expression early during embryonic development.
Neg (not) Positive_regulation (induction) of Gene_expression (expression) of ChAT in neurons
10) Confidence 0.26 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.30 Pain Relevance 0
After the ret-independent initial induction of ChAT and VAChT expression in the majority or even all sympathetic neurons, the cholinergic markers are lost in most cells and become expressed at comparatively high levels in a small subset of sympathetic neurons (Fig. 5).
Neg (independent) Positive_regulation (induction) of Gene_expression (expression) of ChAT in neurons
11) Confidence 0.26 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.06
In the DMV, 1.5 and 3 months rotenone treatment resulted in increased intracellular alpha-synuclein accumulation inside ChAT+ neurons (Figure 3B) when compared to controls (Figure 3A).
Positive_regulation (accumulation) of Gene_expression (neurons) of ChAT in neurons
12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.40 Pain Relevance 0.20
We observed an increase in alpha-synuclein and some large alpha-synuclein intracellular inclusions (2% of the analyzed images) in ChAT+ neurons of IML (>7.5 µm) (Figure 2A–C) as well as increased alpha-synuclein staining in the dorsal horn layer I after 1.5 and 3 months treatment (Figure 2G and 2H) when compared to controls.
Positive_regulation (increase) of Gene_expression (neurons) of ChAT in dorsal horn associated with dorsal horn and spinal cord
13) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.67 Pain Relevance 0.39
phosphorylation, and augmenting choline acetyltransferase (ChAT) expression (de la Monte et al., 2006).
Positive_regulation (augmenting) of Gene_expression (expression) of choline acetyltransferase
14) Confidence 0.10 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.92 Pain Relevance 0.10

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