INT242535

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.46
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra2)
Anatomy Link Frequency
neurons 2
Gfra2 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 116 99.58 Very High Very High Very High
nociceptor 76 63.20 Quite High
Calcitonin gene-related peptide 88 33.44 Quite Low
Nav1.9 4 30.16 Quite Low
sodium channel 12 29.88 Quite Low
tetrodotoxin 12 25.88 Quite Low
Action potential 4 21.48 Low Low
TRP channel 28 14.00 Low Low
c fibre 68 5.00 Very Low Very Low Very Low
substance P 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 264 99.64 Very High Very High Very High
Targeted Disruption 56 23.00 Low Low
Apoptosis 32 5.00 Very Low Very Low Very Low
Death 28 5.00 Very Low Very Low Very Low
Sprains And Strains 24 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 24 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GFRalpha1-expressing DRG neurons are absent in newborn NGF/Bax mutant mice and GFRalpha2 expression is strongly reduced.
Negative_regulation (reduced) of Gene_expression (expression) of GFRalpha2 in neurons associated with nerve growth factor
1) Confidence 0.04 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34
Data on the coexpression of GFRalpha receptors differ between studies (Bennett et al. 1998; Kashiba et al. 2003).Expression of GFRalpha1 and GFRalpha2, but not GFRalpha3, depends on NGF, as shown in newborn NGF/Bax double-mutant mice where GFRalpha1 is undetectable and GFRalpha2 expression is strongly reduced (Luo et al. 2007).
Negative_regulation (reduced) of Gene_expression (expression) of GFRalpha2 associated with nerve growth factor
2) Confidence 0.04 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.18
Moreover, in ret mutant mice, the expression of GFRalpha1 and GFRalpha2 is reduced in DRG.
Negative_regulation (reduced) of Gene_expression (expression) of GFRalpha2
3) Confidence 0.03 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34
m

GFRalpha1 mRNA as analysed by ISH is detectable at E12.5, gradually decreases thereafter and is undetectable at P5 (Nishino et al. 1999). mRNAs for GFRalpha2 and GFRalpha3 are expressed in most SCG cells at E12.5 and subsequently become restricted to smaller subpopulations.

Negative_regulation (decreases) of Gene_expression (expressed) of GFRalpha2 associated with ganglion cysts
4) Confidence 0.03 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.46 Pain Relevance 0

General Comments

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