INT242541

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.67
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Chat (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 7 97.56 Very High Very High Very High
GABAergic 19 91.28 High High
gABA 46 91.04 High High
monoamine 4 85.52 High High
Glutamate 9 77.44 Quite High
Neurotransmitter 11 74.32 Quite High
substance P 14 58.20 Quite High
imagery 26 46.88 Quite Low
Nerve growth factor 29 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 92 99.38 Very High Very High Very High
Ganglion Cysts 130 66.00 Quite High
Death 10 63.76 Quite High
Apoptosis 10 40.88 Quite Low
Umbilical Hernia 24 36.12 Quite Low
Cleft Palate 16 35.52 Quite Low
Ocular Toxicity (including Many Sub-types) 7 5.00 Very Low Very Low Very Low
Sprains And Strains 7 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In VAChT knockout mice the amount of the ACh-synthesizing enzyme choline acetyltransferase (ChAT) is increased at the mRNA and protein levels compared to their wild-type littermates, suggesting that the change in ChAT expression may be related to a compensatory mechanism due to the lack of ACh release [16].
Regulation (change) of Gene_expression (expression) of ChAT associated with targeted disruption
1) Confidence 0.43 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.26 Pain Relevance 0.57
Whether ChAT and VAChT expression is affected remains to be analysed.


Spec (Whether) Regulation (affected) of Gene_expression (expression) of ChAT
2) Confidence 0.32 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.18 Pain Relevance 0.05
Weak CFP expression was visualized in most ChAT immunoreactive somata in the INL and GCL, and in ChAT immunoreactive processes in the IPL (Figure 8C,F).
Regulation (visualized) of Gene_expression (processes) of ChAT
3) Confidence 0.31 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.13 Pain Relevance 0
Consistently, in transgenic mice, where the ChAT promoter drives the GFP expression [ChAT (BAC)-eGFP], we found that there were abundant GFP-positive cells in the VNOs (Fig. 2G).
Regulation (drives) of Gene_expression (expression) of ChAT associated with targeted disruption
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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