INT242546

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.31
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra1)
Anatomy Link Frequency
neurons 1
Gfra1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 87 98.44 Very High Very High Very High
nociceptor 57 90.88 High High
Calcitonin gene-related peptide 66 88.88 High High
TRP channel 21 82.16 Quite High
Neuropeptide 21 81.12 Quite High
ASIC 3 79.12 Quite High
c fibre 51 76.60 Quite High
Nav1.9 3 19.80 Low Low
sodium channel 9 19.52 Low Low
tetrodotoxin 9 15.52 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 198 91.60 High High
Apoptosis 24 72.16 Quite High
Death 21 47.32 Quite Low
Targeted Disruption 42 5.00 Very Low Very Low Very Low
Sprains And Strains 18 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 18 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, ret mutation leads to a reduction of GFRalpha1 and GFRalpha2, but not GFRalpha3, expression.
Neg (not) Negative_regulation (reduction) of GFRalpha1
1) Confidence 0.07 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.43
With ongoing development, GFRalpha1 is lost from sympathetic neurons, whereas GFRalpha2 and 3 are restricted to neuron subpopulations.


Negative_regulation (lost) of GFRalpha1 in neurons
2) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.31 Pain Relevance 0.04
In addition, GFRalpha1- and GFRalpha2-expressing cells are reduced at P2 and P10 in ret mutants by 60% and 25%, respectively (Luo et al. 2007).The results suggest that NGF signalling controls the initial expression of GFRalpha1 and GFRalpha2, whereas ret autoregulates their levels at later stages.
Negative_regulation (reduced) of GFRalpha1 associated with nerve growth factor
3) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.18

General Comments

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