INT242548

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.20
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ret) kinase activity (Ret)
Anatomy Link Frequency
sympathetic 6
neurons 2
ganglia 2
Ret (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 82 99.18 Very High Very High Very High
nociceptor 165 99.16 Very High Very High Very High
Nerve growth factor 204 98.48 Very High Very High Very High
cytokine 7 91.68 High High
TRP channel 49 76.24 Quite High
Calcitonin gene-related peptide 154 40.64 Quite Low
ASIC 7 30.88 Quite Low
c fibre 119 28.36 Quite Low
substance P 59 28.00 Quite Low
calcitonin gene related peptide 11 26.96 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 547 99.18 Very High Very High Very High
Targeted Disruption 141 85.24 High High
Pain 10 17.84 Low Low
Apoptosis 56 5.00 Very Low Very Low Very Low
Death 51 5.00 Very Low Very Low Very Low
Sprains And Strains 42 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 42 5.00 Very Low Very Low Very Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low
Nociception 10 5.00 Very Low Very Low Very Low
Hyperalgesia 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of mRNAs for GFRalpha1, GFRalpha2, GFRalpha3 and ret is dynamically regulated in mouse sympathetic ganglia during embryogenesis (Nishino et al. 1999; Enomoto et al. 2001).
Regulation (regulated) of Gene_expression (expression) of ret in sympathetic
1) Confidence 0.49 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.47 Pain Relevance 0.04
ret expression is regulated differently during the development of mouse sympathetic and sensory ganglia.
Regulation (regulated) of Gene_expression (expression) of ret in ganglia
2) Confidence 0.49 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.42
This shows that a Runx transcription factor is part of the signalling pathways for regulating ret expression and in turn prompts the question regarding the intracellular transduction pathways mediating ret and GFL signalling.



Regulation (regulating) of Gene_expression (expression) of ret
3) Confidence 0.43 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.16
In sympathetic neurons, ret expression is detected before trkA expression and appears correlated with trkC expression instead.
Spec (appears) Regulation (appears) of Gene_expression (expression) of ret in sympathetic
4) Confidence 0.36 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.35
The acquisition of ret expression in trkA-positive neurons during late embryogenesis requires NGF, apart from its survival action, as shown in NGF/Bax double-mutant mice.
Regulation (acquisition) of Gene_expression (expression) of ret in neurons associated with nerve growth factor
5) Confidence 0.36 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.32
In sympathetic neurons, ret expression is detected before trkA expression and appears correlated with trkC expression instead.
Regulation (detected) of Gene_expression (expression) of ret in sympathetic
6) Confidence 0.36 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.32
The importance of trkC signalling for ret expression in vivo remains to be determined.
Regulation (importance) of Gene_expression (expression) of ret
7) Confidence 0.22 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.29
The TG of newborn Brn3a-/- mice also exhibited changes in the expression of the sensory subtype markers TrkA and Ret.
Regulation (changes) of Gene_expression (expression) of Ret associated with trigeminal ganglion
8) Confidence 0.15 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.73 Pain Relevance 0.43

General Comments

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