INT242551

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.01
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ret) kinase activity (Ret)
Anatomy Link Frequency
embryos 2
neurons 2
sympathetic 2
nociceptors 2
Ret (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 78 98.56 Very High Very High Very High
nociceptor 168 98.02 Very High Very High Very High
TRP channel 22 92.36 High High
substance P 27 89.40 High High
Kinase C 1 89.24 High High
Glutamate receptor 1 87.48 High High
calcitonin gene related peptide 11 86.28 High High
Neuropeptide 26 85.76 High High
Calcitonin gene-related peptide 66 79.60 Quite High
mu opioid receptor 4 77.92 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 283 98.56 Very High Very High Very High
Nociception 6 82.00 Quite High
Targeted Disruption 99 73.96 Quite High
INFLAMMATION 20 68.80 Quite High
Pain 26 59.08 Quite High
Death 23 49.92 Quite Low
Repression 7 46.96 Quite Low
Neuropathic Pain 44 5.00 Very Low Very Low Very Low
Apoptosis 24 5.00 Very Low Very Low Very Low
Inflammatory Pain 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most cells lose ret expression by E15.5 and only a subpopulation of sympathetic cells expresses ret at postnatal day 0 (P0).
Negative_regulation (lose) of Gene_expression (expression) of ret in sympathetic
1) Confidence 0.41 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.52 Pain Relevance 0.03
Expression of ret and GFRalpha receptor subunits
Negative_regulation (subunits) of Gene_expression (Expression) of ret
2) Confidence 0.34 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.44
In the trigeminal ganglion of mouse embryos, GFRalpha1 and GFRalpha2 mRNAs can be detected by ISH preceding ret expression (Luukko et al. 1997).
Negative_regulation (preceding) of Gene_expression (expression) of ret in embryos associated with ganglion cysts and trigeminal ganglion
3) Confidence 0.34 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.10 Pain Relevance 0.43
Here we found that high level Ret expression and P2X3 expression were completely eliminated in IB4+ neurons in L-CKO mice (Fig. 1B), whereas their expression in IB4-negative neurons was largely unaffected (Fig. 1B).
Negative_regulation (eliminated) of Gene_expression (expression) of Ret in neurons
4) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.18 Pain Relevance 0.40
Recent work has shown that peptidergic nociceptors maintain postnatal expression of TrkA, while non-peptidergic neurons make a late, Runx1-dependent switch from TrkA to Ret expression [7].
Negative_regulation (switch) of Gene_expression (expression) of Ret in nociceptors associated with nociceptor
5) Confidence 0.24 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.14 Pain Relevance 0.90

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox