INT242557

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.47
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra1)
Anatomy Link Frequency
neurons 2
Gfra1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 87 99.52 Very High Very High Very High
nociceptor 57 66.36 Quite High
TRP channel 21 16.72 Low Low
Calcitonin gene-related peptide 66 5.00 Very Low Very Low Very Low
c fibre 51 5.00 Very Low Very Low Very Low
substance P 24 5.00 Very Low Very Low Very Low
Neuropeptide 21 5.00 Very Low Very Low Very Low
qutenza 15 5.00 Very Low Very Low Very Low
noradrenaline 15 5.00 Very Low Very Low Very Low
Spinal cord 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 198 99.64 Very High Very High Very High
Targeted Disruption 42 25.72 Quite Low
Apoptosis 24 5.00 Very Low Very Low Very Low
Death 21 5.00 Very Low Very Low Very Low
Sprains And Strains 18 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 18 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GFRalpha1-expressing DRG neurons are absent in newborn NGF/Bax mutant mice and GFRalpha2 expression is strongly reduced.
Negative_regulation (absent) of Neg (absent) Gene_expression (neurons) of GFRalpha1-expressing in neurons associated with nerve growth factor
1) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34
Moreover, in ret mutant mice, the expression of GFRalpha1 and GFRalpha2 is reduced in DRG.
Negative_regulation (reduced) of Gene_expression (expression) of GFRalpha1
2) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34
m

GFRalpha1 mRNA as analysed by ISH is detectable at E12.5, gradually decreases thereafter and is undetectable at P5 (Nishino et al. 1999). mRNAs for GFRalpha2 and GFRalpha3 are expressed in most SCG cells at E12.5 and subsequently become restricted to smaller subpopulations.

Negative_regulation (decreases) of Gene_expression (expressed) of GFRalpha1 mRNA associated with ganglion cysts
3) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.47 Pain Relevance 0

General Comments

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