INT242558

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
c fibre 17 76.04 Quite High
Nerve growth factor 34 73.72 Quite High
dorsal root ganglion 24 66.80 Quite High
hyperexcitability 1 55.56 Quite High
TRP channel 7 33.24 Quite Low
nociceptor 27 32.28 Quite Low
Spinal cord 10 26.00 Quite Low
Peripheral nervous system 2 25.44 Quite Low
Calcitonin gene-related peptide 23 5.00 Very Low Very Low Very Low
substance P 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 18 90.96 High High
Death 8 76.40 Quite High
Neurodegenerative Disease 2 69.72 Quite High
Ganglion Cysts 90 66.80 Quite High
Nociception 10 57.84 Quite High
Apoptosis 8 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 6 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the chick, it has been suggested that Runx1 directly activates TrkA transcription and that Runx1 overexpression in progenitors in vivo induces ectopic expression of TrkA [32].
Transcription (transcription) of TrkA
1) Confidence 0.37 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.36 Pain Relevance 0.07
Surprisingly, ret transcript levels are unchanged, whereas trkA mRNA levels increase by 37%.
Transcription (levels) of trkA
2) Confidence 0.30 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.30 Pain Relevance 0.10

General Comments

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