INT242562

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.34
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) plasma membrane (Ntrk3) kinase activity (Ntrk3)
cytoplasm (Ntrk3)
Anatomy Link Frequency
mechanoreceptors 1
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 76 99.68 Very High Very High Very High
Nerve growth factor 140 98.30 Very High Very High Very High
nociceptor 51 96.76 Very High Very High Very High
agonist 10 95.16 Very High Very High Very High
adenocard 2 66.80 Quite High
Serotonin 6 30.80 Quite Low
TRP channel 7 26.76 Quite Low
Central nervous system 4 26.64 Quite Low
antidepressant 2 24.48 Low Low
sSRI 2 21.48 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 153 99.68 Very High Very High Very High
Targeted Disruption 73 99.56 Very High Very High Very High
Apoptosis 16 92.12 High High
Neuroblastoma 2 91.16 High High
Death 25 89.04 High High
Convulsion 4 86.88 High High
Middle Cerebral Artery Infarction 2 83.12 Quite High
Repression 7 82.08 Quite High
Stroke 2 79.92 Quite High
Necrosis 2 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Newborn Brn3a knockout mice fail to express TrkC, which is associated in the TG with mechanoreceptors, plus a set of functional genes associated with nociceptor subtypes.
TrkC Binding (associated) of in mechanoreceptors associated with targeted disruption, nociceptor and trigeminal ganglion
1) Confidence 0.26 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.60 Pain Relevance 0.35
This compound binds TrkA, but not TrkB or TrkC, and causes receptor dimerization and phosphorylation.
TrkC Binding (binds) of
2) Confidence 0.18 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.52 Pain Relevance 0.12
The importance of trkC signalling for ret expression in vivo remains to be determined.
trkC Binding (signalling) of
3) Confidence 0.18 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.29
NGF binds the TrkA receptor, BDNF and NT-4/5 bind the TrkB receptor, and NT-3 primarily binds the TrkC receptor [5].
TrkC receptor Binding (binds) of associated with nerve growth factor
4) Confidence 0.13 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.22 Pain Relevance 0.24

General Comments

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