INT242568

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 1.52
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gfra4) extracellular region (Gfra4) plasma membrane (Gfra4)
Anatomy Link Frequency
sensory neurons 1
ganglia 1
Gfra4 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 319 99.52 Very High Very High Very High
Neuropeptide 77 93.00 High High
nociceptor 209 92.92 High High
substance P 88 89.40 High High
c fibre 187 87.84 High High
Calcitonin gene-related peptide 242 83.68 Quite High
Nav1.9 11 80.40 Quite High
sodium channel 33 80.12 Quite High
TRP channel 77 79.52 Quite High
tetrodotoxin 33 76.12 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 726 98.84 Very High Very High Very High
Targeted Disruption 154 88.52 High High
INFLAMMATION 22 68.80 Quite High
Death 77 65.00 Quite High
Apoptosis 88 48.56 Quite Low
Sprains And Strains 66 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 66 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
Hyperalgesia 11 5.00 Very Low Very Low Very Low
Nociception 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ret and GFRalpha expression
Gene_expression (expression) of GFRalpha
1) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.40
Expression of ret and GFRalpha receptor subunits
Gene_expression (Expression) of GFRalpha receptor
2) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.44
There is a large but incomplete overlap of ret and GFRalpha expression ret expression overlaps largely with expression of GFRalpha1, GFRalpha2 and GFRalpha3.
Gene_expression (expression) of GFRalpha
3) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.60
GFL overexpression and GFRalpha mutation affect the mechanical and thermal responsiveness of sensory neurons.
Gene_expression (overexpression) of GFRalpha in sensory neurons
4) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.32
However, as GFRalpha expression is initiated in the second embryonic week, lack of GFRalpha expression in newborn NGF/Bax mutant animals might not provide a reliable picture of signalling requirements during initial differentiation.
Gene_expression (expression) of GFRalpha associated with nerve growth factor
5) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.25
ret and GFRalpha expression patterns in sympathetic ganglia
Gene_expression (expression) of GFRalpha in ganglia
6) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.44 Pain Relevance 0.04
ret and GFRalpha expression
Gene_expression (expression) of GFRalpha
7) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.19 Pain Relevance 0.05
However, as GFRalpha expression is initiated in the second embryonic week, lack of GFRalpha expression in newborn NGF/Bax mutant animals might not provide a reliable picture of signalling requirements during initial differentiation.
Gene_expression (expression) of GFRalpha associated with nerve growth factor
8) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.26
Data on the coexpression of GFRalpha receptors differ between studies (Bennett et al. 1998; Kashiba et al. 2003).Expression of GFRalpha1 and GFRalpha2, but not GFRalpha3, depends on NGF, as shown in newborn NGF/Bax double-mutant mice where GFRalpha1 is undetectable and GFRalpha2 expression is strongly reduced (Luo et al. 2007).
Gene_expression (coexpression) of GFRalpha associated with nerve growth factor
9) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.18
m

ret and GFRalpha expression in DRG

Neg (not) Gene_expression (expression) of GFRalpha
10) Confidence 0.01 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.33 Pain Relevance 0
ret and GFRalpha subunits
Gene_expression (subunits) of GFRalpha
11) Confidence 0.01 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.43 Pain Relevance 0.04

General Comments

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