INT242572

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.29
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ret) kinase activity (Ret)
Anatomy Link Frequency
neurons 2
sympathetic 2
DRG 2
Ret (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 121 99.96 Very High Very High Very High
nociceptor 163 98.56 Very High Very High Very High
TRP channel 29 96.44 Very High Very High Very High
Kinase C 1 93.32 High High
Glutamate receptor 1 91.56 High High
cytokine 4 91.08 High High
Pain 17 63.16 Quite High
Inflammation 22 50.00 Quite Low
Neuropeptide 29 44.84 Quite Low
sodium channel 13 31.88 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 288 96.20 Very High Very High Very High
Targeted Disruption 74 78.04 Quite High
Pain 24 63.16 Quite High
INFLAMMATION 22 50.00 Quite Low
Neuropathic Pain 44 5.00 Very Low Very Low Very Low
Apoptosis 32 5.00 Very Low Very Low Very Low
Death 29 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 24 5.00 Very Low Very Low Very Low
Sprains And Strains 24 5.00 Very Low Very Low Very Low
Inflammatory Pain 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The importance of trkC signalling for ret expression in vivo remains to be determined.
Positive_regulation (importance) of Gene_expression (expression) of ret
1) Confidence 0.40 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.29
During the third week of embryonic development, an increasing number of small neurons in DRG initiates ret expression, while expression in sympathetic ganglia is restricted to a subset of neurons thus distinguishing a “progressive increase” from a “progressive restriction” of gene expression to neuron subpopulations (arrow NGF requirement for the increase in the ret-positive population in DRG)Fig. 5Cholineric differentiation of sympathetic neurons during mouse embryogenesis.
Positive_regulation (initiates) of Gene_expression (expression) of ret in DRG associated with nerve growth factor
2) Confidence 0.40 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.10 Pain Relevance 0.05
The acquisition of ret expression in trkA-positive neurons during late embryogenesis requires NGF, apart from its survival action, as shown in NGF/Bax double-mutant mice.
Positive_regulation (requires) of Gene_expression (expression) of ret in neurons associated with nerve growth factor
3) Confidence 0.37 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.33
In sympathetic neurons, ret expression is detected before trkA expression and appears correlated with trkC expression instead.
Positive_regulation (detected) of Gene_expression (expression) of ret in sympathetic
4) Confidence 0.37 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.32
We reported previously that Runx1 is partially required for the expression of Ret and the ATP-gated channel P2X3 [14].
Positive_regulation (required) of Gene_expression (expression) of Ret
5) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.20 Pain Relevance 0.32
In collaboration with the Runx1-induced ectopic expression of the growth factor receptors TrkA and RET, these extrinsic factors may significantly contribute to survival and possibly also to differentiation of the DOX-treated, transplanted bNCSCs.
Positive_regulation (induced) of Gene_expression (expression) of RET
6) Confidence 0.30 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0 Pain Relevance 0.25

General Comments

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