INT242594

Context Info Confidence 0.21 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.08

cell proliferation (Gdnf) signal transduction (Ret) extracellular space (Gdnf) extracellular region (Gdnf) kinase activity (Ret)

Anatomy Link Frequency glial cell 1 Gdnf (Mus musculus) Ret (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 29 78.00 Peripheral nervous system 1 40.48 Calcitonin gene-related peptide 22 5.00 nociceptor 19 5.00 c fibre 17 5.00 substance P 8 5.00 Neuropeptide 7 5.00 TRP channel 7 5.00 qutenza 5 5.00 noradrenaline 5 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 66 50.00 Targeted Disruption 14 5.00 Apoptosis 8 5.00 Death 7 5.00 Sprains And Strains 6 5.00 Ocular Toxicity (including Many Sub-types) 6 5.00 INFLAMMATION 2 5.00 Pain 1 5.00 Hyperalgesia 1 5.00 Nociception 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cloning of the genes coding for glial cell-line-derived neurotrophic factor (GDNF), neurturin, artemin and persephin and their cell surface receptors GFRalpha1 to GFRalpha4 acting in a complex with the receptor tyrosine kinase ret (“rearranged during transfection” proto-oncogene; for a review, see Airaksinen and Saarma 2002; Fig. 1) has allowed the analysis of their in vivo function in mutant mice.

GDNF Binding (complex) of ret in glial cell

1) Confidence 0.21 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.08

General Comments

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