INT242598

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.38
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
plasma membrane (Gfra2)
Anatomy Link Frequency
peripheral nervous system 3
glial cell 1
Gdnf (Mus musculus)
Gfra2 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 3 99.84 Very High Very High Very High
Nerve growth factor 87 64.32 Quite High
neurotrophin 3 9 58.56 Quite High
Calcitonin gene-related peptide 66 5.00 Very Low Very Low Very Low
nociceptor 57 5.00 Very Low Very Low Very Low
c fibre 51 5.00 Very Low Very Low Very Low
substance P 24 5.00 Very Low Very Low Very Low
Neuropeptide 21 5.00 Very Low Very Low Very Low
TRP channel 21 5.00 Very Low Very Low Very Low
qutenza 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 6 98.74 Very High Very High Very High
Skin Cancer 2 93.08 High High
Anaplastic Astrocytoma 3 92.16 High High
Ganglion Cysts 198 50.00 Quite Low
Targeted Disruption 42 5.00 Very Low Very Low Very Low
Apoptosis 24 5.00 Very Low Very Low Very Low
Death 21 5.00 Very Low Very Low Very Low
Sprains And Strains 20 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 18 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They include Lgi1, which causes a subtype of inherited epilepsy that displays autosomal dominance with incomplete penetrance; Gfra2, a receptor for glial cell line-derived neurotrophic factor GDNF that has been linked to kindling epilepsy; Unc5a, a netrin-1 receptor important in neurodevelopment; and Cspg4, a membrane chondroitin sulfate proteoglycan associated with malignant melanoma and astrocytoma in human.
GDNF Binding (receptor) of Gfra2 in glial cell associated with anaplastic astrocytoma, epilepsy and skin cancer
1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2973945 Disease Relevance 0.38 Pain Relevance 0
Fig. 1Cell surface receptors for GDNF family ligands and neurotrophins in the peripheral nervous system. a The GDNF family ligands, viz. glial cell-line-derived neurotrophic factor (GDNF), neurturin (NRTN) and artemin (ARTN), bind to the alpha receptor subunits GFRalpha1, GFRalpha2 and GFRalpha3, respectively.
GDNF Binding (bind) of GFRalpha2 in peripheral nervous system associated with peripheral nervous system
2) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.17
Fig. 1Cell surface receptors for GDNF family ligands and neurotrophins in the peripheral nervous system. a The GDNF family ligands, viz. glial cell-line-derived neurotrophic factor (GDNF), neurturin (NRTN) and artemin (ARTN), bind to the alpha receptor subunits GFRalpha1, GFRalpha2 and GFRalpha3, respectively.
cell-line-derived neurotrophic factor Binding (bind) of GFRalpha2 in peripheral nervous system associated with peripheral nervous system
3) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.17
Fig. 1Cell surface receptors for GDNF family ligands and neurotrophins in the peripheral nervous system. a The GDNF family ligands, viz. glial cell-line-derived neurotrophic factor (GDNF), neurturin (NRTN) and artemin (ARTN), bind to the alpha receptor subunits GFRalpha1, GFRalpha2 and GFRalpha3, respectively.
GDNF Binding (bind) of GFRalpha2 in peripheral nervous system associated with peripheral nervous system
4) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.17

General Comments

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