INT242610

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.17

extracellular region (Nrtn) plasma membrane (Gfra2)

Anatomy Link Frequency peripheral nervous system 1 Gfra2 (Mus musculus) Nrtn (Mus musculus)

Pain Link Frequency Relevance Heat Peripheral nervous system 1 98.28 Nerve growth factor 29 64.32 neurotrophin 3 3 58.56 Calcitonin gene-related peptide 22 5.00 nociceptor 19 5.00 c fibre 17 5.00 substance P 8 5.00 Neuropeptide 7 5.00 TRP channel 7 5.00 qutenza 5 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 66 50.00 Targeted Disruption 14 5.00 Apoptosis 8 5.00 Death 7 5.00 Sprains And Strains 6 5.00 Ocular Toxicity (including Many Sub-types) 6 5.00 INFLAMMATION 2 5.00 Pain 1 5.00 Hyperalgesia 1 5.00 Nociception 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Fig. 1Cell surface receptors for GDNF family ligands and neurotrophins in the peripheral nervous system. a The GDNF family ligands, viz. glial cell-line-derived neurotrophic factor (GDNF), neurturin (NRTN) and artemin (ARTN), bind to the alpha receptor subunits GFRalpha1, GFRalpha2 and GFRalpha3, respectively.

GFRalpha2 Binding (bind) of neurturin in peripheral nervous system associated with peripheral nervous system

1) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.17

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