INT242613

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.52

signal transduction (Ret) plasma membrane (Gfra2) kinase activity (Ret)

Anatomy Link Frequency neuron 1 Gfra2 (Mus musculus) Ret (Mus musculus)

Pain Link Frequency Relevance Heat nociceptor 19 100.00 TRP channel 7 95.20 Calcitonin gene-related peptide 22 85.24 ASIC 1 75.48 c fibre 17 72.96 Nerve growth factor 29 5.00 substance P 8 5.00 Neuropeptide 7 5.00 qutenza 5 5.00 noradrenaline 5 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 66 50.00 Targeted Disruption 14 5.00 Apoptosis 8 5.00 Death 7 5.00 Sprains And Strains 6 5.00 Ocular Toxicity (including Many Sub-types) 6 5.00 INFLAMMATION 2 5.00 Pain 1 5.00 Hyperalgesia 1 5.00 Nociception 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results show that ret promotes the generation of trkA-negative nociceptors and GFRalpha1- and GFRalpha2-positive DRG neuron populations.

GFRalpha2-positive Binding (generation) of ret in neuron associated with nociceptor

1) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.52

General Comments

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