INT242623

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.31
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) extracellular region (Ntf3) plasma membrane (Ntrk3)
cytoplasmic membrane-bounded vesicle (Ntf3) kinase activity (Ntrk3) cytoplasm (Ntrk3)
Anatomy Link Frequency
brain 2
neurons 1
neurites 1
Ntf3 (Mus musculus)
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
neurotrophin 3 6 100.00 Very High Very High Very High
Nerve growth factor 117 99.04 Very High Very High Very High
dorsal root ganglion 55 98.26 Very High Very High Very High
Peripheral nervous system 6 72.12 Quite High
Spinal cord 22 71.60 Quite High
Glutamate 6 43.36 Quite Low
Neurotransmitter 6 39.36 Quite Low
Neuropeptide 16 18.72 Low Low
Hippocampus 8 14.96 Low Low
Intracerebroventricular 3 11.68 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 63 98.84 Very High Very High Very High
Ganglion Cysts 199 98.26 Very High Very High Very High
Nociception 14 87.40 High High
Necrosis 1 79.00 Quite High
Cancer 4 78.64 Quite High
Neurological Disease 4 77.64 Quite High
Apoptosis 38 66.68 Quite High
Death 28 60.16 Quite High
Toxicity 4 42.56 Quite Low
Injury 11 34.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior studies showed that DRG explants from Runx3-knockout mouse embryos extended short neurites in the presence of NT3, a ligand for TrkC, but not in the presence of NGF, a ligand for TrkA [16].
NT3 Binding (ligand) of TrkC in neurites associated with targeted disruption and dorsal root ganglion
1) Confidence 0.22 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.87 Pain Relevance 0.35
Modified from Airaksinen and Saarma (2002). b The neurotrophins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) bind with high affinity to the tyrosine kinase receptors trkA, trkB and trkC, respectively.
NT3 Binding (bind) of trkC in brain associated with neurotrophin 3 and nerve growth factor
2) Confidence 0.14 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.28
Modified from Airaksinen and Saarma (2002). b The neurotrophins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) bind with high affinity to the tyrosine kinase receptors trkA, trkB and trkC, respectively.
neurotrophin 3 Binding (bind) of trkC in brain associated with neurotrophin 3 and nerve growth factor
3) Confidence 0.14 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.28
Neurotrophins exert their biological functions on neurons through two transmembrane receptors: the p75 neurotrophin receptor (p75NTR) and the Trk receptor tyrosine kinases (NGF binds to TrkA, BDNF and NT-4/5 bind to TrkB, and NT-3 preferentially binds to TrkC) [3], [4].
NT-3 Binding (binds) of TrkC in neurons associated with nerve growth factor
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.08 Pain Relevance 0.14
NGF binds the TrkA receptor, BDNF and NT-4/5 bind the TrkB receptor, and NT-3 primarily binds the TrkC receptor [5].
NT-3 Binding (binds) of TrkC receptor associated with nerve growth factor
5) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.22 Pain Relevance 0.24

General Comments

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