INT242624

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.48
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) signal transduction (Ngf)
extracellular space (Ngf) extracellular region (Ngf) plasma membrane (Ntrk2)
Anatomy Link Frequency
brain 2
neurons 1
Ngf (Mus musculus)
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 70 100.00 Very High Very High Very High
neurotrophin 3 6 100.00 Very High Very High Very High
Peripheral nervous system 2 75.00 Quite High
Central nervous system 10 57.20 Quite High
depression 149 50.00 Quite Low
Glutamate 6 40.24 Quite Low
Neurotransmitter 6 38.64 Quite Low
long-term potentiation 4 27.28 Quite Low
Neuropeptide 14 18.00 Low Low
Hippocampus 89 10.80 Low Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 18 80.52 Quite High
Neurological Disease 4 79.76 Quite High
Ganglion Cysts 140 70.24 Quite High
Hyperplasia 2 51.68 Quite High
Depression 193 50.00 Quite Low
Mental Disorders 12 39.52 Quite Low
Toxicity 1 39.44 Quite Low
Apoptosis 44 35.84 Quite Low
Suicidal Behaviour 246 31.56 Quite Low
Injury 4 31.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurotrophins exert their biological functions on neurons through two transmembrane receptors: the p75 neurotrophin receptor (p75NTR) and the Trk receptor tyrosine kinases (NGF binds to TrkA, BDNF and NT-4/5 bind to TrkB, and NT-3 preferentially binds to TrkC) [3], [4].
NGF Binding (bind) of TrkB in neurons associated with nerve growth factor
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.08 Pain Relevance 0.14
The interaction of neurotrophins with the Trk receptors is specific: NGF binds with TrkA, BDNF and NT 4 both bind with TrkB, and NT 3 binds with the highest affinity to TrkC but is also capable of signaling through TrkA and TrkB.
NGF Binding (signaling) of TrkB associated with nerve growth factor
2) Confidence 0.14 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.13 Pain Relevance 0.20
The interaction of neurotrophins with the Trk receptors is specific: NGF binds with TrkA, BDNF and NT 4 both bind with TrkB, and NT 3 binds with the highest affinity to TrkC but is also capable of signaling through TrkA and TrkB.
NGF Binding (bind) of TrkB associated with nerve growth factor
3) Confidence 0.13 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.13 Pain Relevance 0.20
Modified from Airaksinen and Saarma (2002). b The neurotrophins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) bind with high affinity to the tyrosine kinase receptors trkA, trkB and trkC, respectively.
nerve growth factor Binding (bind) of trkB in brain associated with neurotrophin 3 and nerve growth factor
4) Confidence 0.13 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.29
Modified from Airaksinen and Saarma (2002). b The neurotrophins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) bind with high affinity to the tyrosine kinase receptors trkA, trkB and trkC, respectively.
NGF Binding (bind) of trkB in brain associated with neurotrophin 3 and nerve growth factor
5) Confidence 0.13 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.29

General Comments

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