INT242625

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.34
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf, Pax3) extracellular space (Gdnf) extracellular region (Gdnf)
nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
neurons 1
nociceptor 1
Gdnf (Mus musculus)
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 16 100.00 Very High Very High Very High
nociceptor 38 99.04 Very High Very High Very High
Neuropeptide 14 98.04 Very High Very High Very High
Nerve growth factor 58 95.08 Very High Very High Very High
sodium channel 6 91.64 High High
Freund adjuvant 2 83.08 Quite High
Inflammation 4 81.64 Quite High
c fibre 34 71.44 Quite High
Spinal cord 8 69.88 Quite High
qutenza 10 67.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 81.64 Quite High
Targeted Disruption 28 80.00 Quite High
Ganglion Cysts 132 61.32 Quite High
Apoptosis 16 5.00 Very Low Very Low Very Low
Death 14 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 12 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In dissociated rat DRG neurons grown for 1 week in culture, GDNF increases SP levels as analysed by radioimmunoassay (Skoff and Adler 2006).
GDNF Positive_regulation (increases) of SP in neurons associated with substance p
1) Confidence 0.01 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.26 Pain Relevance 0.61
In vitro, GDNF increases the proportion of neurons positive for SP and TRPV1, markers for nociceptor subpopulations.
GDNF Positive_regulation (increases) of SP in nociceptor associated with nociceptor and substance p
2) Confidence 0.01 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.08 Pain Relevance 0.54

General Comments

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