INT242626

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.15
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.27
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) signal transduction (Ngf) extracellular space (Ngf)
extracellular region (Ngf) plasma membrane (Ntrk3) kinase activity (Ntrk3)
Anatomy Link Frequency
brain 2
Ngf (Mus musculus)
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 62 100.00 Very High Very High Very High
neurotrophin 3 6 100.00 Very High Very High Very High
Peripheral nervous system 2 75.00 Quite High
Central nervous system 5 57.20 Quite High
depression 73 50.00 Quite Low
Neurotransmitter 6 39.36 Quite Low
long-term potentiation 2 27.28 Quite Low
Neuropeptide 14 18.72 Low Low
Hippocampus 43 10.80 Low Low
Catecholamine 2 6.08 Low Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 9 80.52 Quite High
Ganglion Cysts 132 70.96 Quite High
Hyperplasia 1 51.68 Quite High
Depression 95 50.00 Quite Low
Mental Disorders 6 35.12 Quite Low
Suicidal Behaviour 123 31.56 Quite Low
Stress 25 20.80 Low Low
Cognitive Disorder 4 14.24 Low Low
Frailty 1 9.20 Low Low
Targeted Disruption 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modified from Airaksinen and Saarma (2002). b The neurotrophins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) bind with high affinity to the tyrosine kinase receptors trkA, trkB and trkC, respectively.
NGF Binding (bind) of trkC in brain associated with neurotrophin 3 and nerve growth factor
1) Confidence 0.15 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.29
Modified from Airaksinen and Saarma (2002). b The neurotrophins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) bind with high affinity to the tyrosine kinase receptors trkA, trkB and trkC, respectively.
nerve growth factor Binding (bind) of trkC in brain associated with neurotrophin 3 and nerve growth factor
2) Confidence 0.15 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.29
The interaction of neurotrophins with the Trk receptors is specific: NGF binds with TrkA, BDNF and NT 4 both bind with TrkB, and NT 3 binds with the highest affinity to TrkC but is also capable of signaling through TrkA and TrkB.
NGF Binding (binds) of TrkC associated with nerve growth factor
3) Confidence 0.03 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.13 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox