INT242627

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf, Ret) extracellular space (Ngf) extracellular region (Ngf)
kinase activity (Ret)
Anatomy Link Frequency
neurons 2
Ngf (Mus musculus)
Ret (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 29 100.00 Very High Very High Very High
Calcitonin gene-related peptide 22 45.92 Quite Low
nociceptor 19 5.00 Very Low Very Low Very Low
c fibre 17 5.00 Very Low Very Low Very Low
substance P 8 5.00 Very Low Very Low Very Low
Neuropeptide 7 5.00 Very Low Very Low Very Low
TRP channel 7 5.00 Very Low Very Low Very Low
qutenza 5 5.00 Very Low Very Low Very Low
noradrenaline 5 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 8 98.48 Very High Very High Very High
Ganglion Cysts 66 50.00 Quite Low
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 6 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, ret expression is NGF-dependent as, in NGF/Bax (bcl-2 associated pro-apoptotic protein) double-mutants, only a few ret-positive neurons are present at P0 and these are trkA-negative (Luo et al. 2007).In mature animals, the overlap of ret and trkA expression is limited and amounts to ~5%–15% in mouse lumbar segment 5 (L5) DRG (Molliver et al. 1997; Orozco et al. 2001).
NGF Positive_regulation (dependent) of Gene_expression (expression) of ret in neurons associated with nerve growth factor and apoptosis
1) Confidence 0.32 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.10 Pain Relevance 0.10

General Comments

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