INT242642

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.38
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ngfr) Golgi apparatus (Ngfr) cytoplasm (Ngfr)
signal transduction (Ngfr) extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
BDNF (Homo sapiens)
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
neurotrophin 3 3 99.52 Very High Very High Very High
Nerve growth factor 249 97.84 Very High Very High Very High
Spinal cord 20 97.84 Very High Very High Very High
Peripheral nervous system 9 66.52 Quite High
Hippocampus 20 54.68 Quite High
Neurotransmitter 3 46.24 Quite Low
Neuropeptide 7 25.60 Quite Low
Catecholamine 1 12.96 Low Low
noradrenaline 5 10.96 Low Low
Calcitonin gene-related peptide 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 98.92 Very High Very High Very High
Necrosis 4 98.68 Very High Very High Very High
Spinal Cord Injury 12 98.20 Very High Very High Very High
Neurodegenerative Disease 8 96.68 Very High Very High Very High
Death 39 96.40 Very High Very High Very High
Convulsion 8 87.52 High High
Apoptosis 24 86.16 High High
Ganglion Cysts 70 77.84 Quite High
Dyskinesias 4 61.96 Quite High
Disease 84 47.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One complication, however, is that neurotrophins also bind to p75NTR.
neurotrophin Binding (bind) of p75NTR
1) Confidence 0.21 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.76 Pain Relevance 0.08
All neurotrophins bind p75NTR with similar affinity (Kd~10-9 M), but binding to the Trk receptors is more selective.
neurotrophin Binding (bind) of p75NTR
2) Confidence 0.21 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.17 Pain Relevance 0.24
The neurotrophins bind two classes of receptor, the common p75NTR, which is a member of the tumor necrosis factor receptor family [2,3], and the tropomyosin-related kinase (Trk) receptors, members of the large tyrosine kinase receptor family [4].
neurotrophin Binding (bind) of p75NTR associated with necrosis and cancer
3) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.20 Pain Relevance 0.15
All neurotrophins bind p75NTR with similar affinity (Kd~10-9 M), but binding to the Trk receptors is more selective.
neurotrophin Binding (binding) of p75NTR
4) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.17 Pain Relevance 0.27
NT3 may also act via trkA. p75 is a low affinity neurotrophin receptor
neurotrophin Binding (receptor) of p75 associated with neurotrophin 3
5) Confidence 0.10 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.08 Pain Relevance 0.27

General Comments

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