INT24266

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Context Info
Confidence 0.37
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.55
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (IKZF1) intracellular (IKZF1) cell cycle (IKZF1)
DNA binding (IKZF1) cytoplasm (IKZF1)
Anatomy Link Frequency
myocytes 1
bowel 1
IKZF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 3 100.00 Very High Very High Very High
action potential duration 48 99.22 Very High Very High Very High
Calcium channel 2 99.20 Very High Very High Very High
local anesthetic 1 98.14 Very High Very High Very High
Action potential 32 81.60 Quite High
Crohn's disease 1 78.68 Quite High
anesthesia 9 67.84 Quite High
trk C 1 65.52 Quite High
abdominal pain 1 62.60 Quite High
Inflammation 1 61.52 Quite High
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 5 96.48 Very High Very High Very High
Shock 71 96.04 Very High Very High Very High
Arrhythmias 2 Under Development 26 82.24 Quite High
Disease 1 78.36 Quite High
Inflammatory Bowel Disease 2 77.88 Quite High
Cv General 2 Under Development 1 75.00 Quite High
Brain Hemorrhage 2 73.04 Quite High
Aging 2 68.24 Quite High
Diarrhoea 1 63.48 Quite High
Abdominal Pain 1 62.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel.
Negative_regulation (Decreased) of IK1 in bowel associated with potassium channel
1) Confidence 0.37 Published 2003 Journal Neuroreport Section Title Doc Link 12598727 Disease Relevance 0.28 Pain Relevance 0.22
The local anesthetic agent bupivacaine increases action potential duration in isolated frog atrial myocytes, and blocks two potassium conductances, IK and IK1.
Negative_regulation (blocks) of IK1 in myocytes associated with action potential duration and local anesthetic
2) Confidence 0.23 Published 1988 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2450583 Disease Relevance 0 Pain Relevance 0.23
Amiodarone effectively blocks both the sodium and calcium channels and beta-adrenoceptors, in addition to blocking several potassium currents including IKr, IKs, Ito, IK1, IKACh and IKNa.
Negative_regulation (blocking) of IK1 associated with calcium channel
3) Confidence 0.15 Published 2002 Journal Circ. J. Section Abstract Doc Link 12197602 Disease Relevance 0.37 Pain Relevance 0.12
Inhibition of the typical outward currents IK1 and Ito do not reduce the ?
Negative_regulation (Inhibition) of IK1
4) Confidence 0.13 Published 2010 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2803603 Disease Relevance 0.57 Pain Relevance 0.11
The present experiments showed that: (i) ginkgolide A prolonged the APD, but ginkgolides B and C shortened APD; (ii) quercetin prolonged the APD; (iii) the constituents also inhibited the Vmax and the RP was unaffected; (iv) ginkgolides A and B increased ICa and IK, and decreased IK1; (v) ginkgolide C failed to affect the ICa but increased the IK; (vi) quercetin inhibited ICa, and enhanced IK but decreased IK1; and (vii) these responses were almost reversible after a washout.
Negative_regulation (decreased) of IK1 associated with action potential duration
5) Confidence 0.05 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538515 Disease Relevance 0.20 Pain Relevance 0.14
The present experiments showed that: (i) ginkgolide A prolonged the APD, but ginkgolides B and C shortened APD; (ii) quercetin prolonged the APD; (iii) the constituents also inhibited the Vmax and the RP was unaffected; (iv) ginkgolides A and B increased ICa and IK, and decreased IK1; (v) ginkgolide C failed to affect the ICa but increased the IK; (vi) quercetin inhibited ICa, and enhanced IK but decreased IK1; and (vii) these responses were almost reversible after a washout.
Negative_regulation (decreased) of IK1 associated with action potential duration
6) Confidence 0.05 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538515 Disease Relevance 0.12 Pain Relevance 0.15

General Comments

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