INT24278

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1987
Last Reported 2010
Negated 7
Speculated 2
Reported most in Body
Documents 33
Total Number 36
Disease Relevance 26.70
Pain Relevance 4.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT4) Golgi apparatus (FUT4) carbohydrate metabolic process (FUT4)
Anatomy Link Frequency
pancreas 5
ducts 2
monocytes 2
skin 2
epithelial cells 1
FUT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 231 100.00 Very High Very High Very High
Chronic pancreatitis 62 100.00 Very High Very High Very High
Pain 7 78.00 Quite High
ischemia 1 72.28 Quite High
peptic ulcer disease 7 69.84 Quite High
midbrain 1 46.56 Quite Low
cytokine 146 44.72 Quite Low
vincristine 5 28.72 Quite Low
abdominal pain 3 17.44 Low Low
anesthesia 20 12.32 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 247 100.00 Very High Very High Very High
Pancreatitis 64 100.00 Very High Very High Very High
Pancreatic Cancer 131 99.98 Very High Very High Very High
Cancer 187 99.92 Very High Very High Very High
Keloid Scars 309 99.72 Very High Very High Very High
Lymphatic System Cancer 64 99.28 Very High Very High Very High
Gastritis 17 99.12 Very High Very High Very High
Hyperplasia 16 98.92 Very High Very High Very High
Infection 71 98.84 Very High Very High Very High
Sprains And Strains 299 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
C-kitpos stem cells derived from amniotic fluid (hAFSC) can be easily propagated in vitro, maintaining stem cell-like properties such as pluripotentiality as well as expression of Oct-4, SSEA-4, CD90 and CD105 [9].
Gene_expression (expression) of SSEA in stem cell
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0.70 Pain Relevance 0.04
The present comparative immunohistochemical study used tissues of normal pancreas, chronic pancreatitis, and pancreatic cancer to determine the normal expression of Lex and Ley antigens in the pancreas and to elucidate any cancer-associated alterations.
Spec (determine) Gene_expression (expression) of Lex in pancreas associated with cancer, pancreatic cancer and chronic pancreatitis
2) Confidence 0.70 Published 1988 Journal Cancer Res. Section Abstract Doc Link 3335015 Disease Relevance 0.82 Pain Relevance 0.19
The discrepant expression between Lex and Ley antigens in these tissues implies altered regulation of fucosyltransferase activity associated with the malignant state.
Gene_expression (expression) of Lex associated with malignant neoplastic disease
3) Confidence 0.70 Published 1988 Journal Cancer Res. Section Abstract Doc Link 3335015 Disease Relevance 1.01 Pain Relevance 0.16
The frequency of Lex-related antigen expression in pancreatic cancer tissues was lowest in poorly differentiated cancers.
Gene_expression (expression) of Lex associated with cancer and pancreatic cancer
4) Confidence 0.70 Published 1988 Journal Cancer Res. Section Abstract Doc Link 3335015 Disease Relevance 1.05 Pain Relevance 0.26
Lex-related antigens were not expressed in normal pancreas, expressed in only 10-20% of chronic pancreatitis tissues, but expressed in 50-70% of pancreatic cancer tissues.
Neg (not) Gene_expression (expressed) of Lex in pancreas associated with pancreatic cancer and chronic pancreatitis
5) Confidence 0.70 Published 1988 Journal Cancer Res. Section Abstract Doc Link 3335015 Disease Relevance 0.98 Pain Relevance 0.25
Lex and Ley antigen expression in human pancreatic cancer.
Gene_expression (expression) of Lex associated with pancreatic cancer
6) Confidence 0.70 Published 1988 Journal Cancer Res. Section Title Doc Link 3335015 Disease Relevance 0.58 Pain Relevance 0.12
Lex-related antigens were not expressed in normal pancreas, expressed in only 10-20% of chronic pancreatitis tissues, but expressed in 50-70% of pancreatic cancer tissues.
Neg (not) Gene_expression (expressed) of Lex in pancreas associated with pancreatic cancer and chronic pancreatitis
7) Confidence 0.70 Published 1988 Journal Cancer Res. Section Abstract Doc Link 3335015 Disease Relevance 1.05 Pain Relevance 0.26
As found in the majority of cases, Reed-Stenberg cells with positive expressions of CD30 and/or CD15, and negative expressions of CD20, CD3 and CD4, corroborate the diagnosis (Table 2).
Gene_expression (expressions) of CD15
8) Confidence 0.66 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2886079 Disease Relevance 1.11 Pain Relevance 0
The sdiLex antigen consists of two repetitive and fucosylated Lex antigens terminally substituted with ?
Gene_expression (antigen) of Lex
9) Confidence 0.65 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.08 Pain Relevance 0
In our transplantation experiment, donor cells did not express undifferentiated markers, such as Oct-3 and SSEA-4.
Neg (not) Gene_expression (express) of SSEA
10) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708355 Disease Relevance 0 Pain Relevance 0
Coexpression among the Ley-related antigens was less common than with the Lex-related antigens.
Gene_expression (Coexpression) of Lex
11) Confidence 0.61 Published 1988 Journal Cancer Res. Section Abstract Doc Link 3335015 Disease Relevance 1.33 Pain Relevance 0.29
Lex-related antigens were not expressed in normal pancreas, expressed in only 10-20% of chronic pancreatitis tissues, but expressed in 50-70% of pancreatic cancer tissues.
Neg (not) Gene_expression (expressed) of Lex in pancreas associated with pancreatic cancer and chronic pancreatitis
12) Confidence 0.61 Published 1988 Journal Cancer Res. Section Abstract Doc Link 3335015 Disease Relevance 0.97 Pain Relevance 0.25
The relatively increased expression of two major markers for embryonic and mesenchymal stem cells [54], [64], [65], Oct-4 and SSEA-4, in keloid tissues as compared to matched normal skin was further confirmed by Western blot (Figure 1B), suggesting that keloid may harbor more postnatal stem cells than normal skin.
Gene_expression (expression) of SSEA in skin associated with keloid scars
13) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.75 Pain Relevance 0.04
However, IL-6 showed no obvious effects on SSEA-4 expression in both SKPs and KPCs as determined by flow cytometry (Figure S5A).
Gene_expression (expression) of SSEA
14) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.11 Pain Relevance 0
The relatively abundant expression of two major markers for embryonic and mesenchymal stem cells [54], [64], [65], Oct-4 and SSEA-4, in keloid as compared to normal skin tissues, suggests the presence of postnatal stem cells in pathologic scar and may contribute to its persistent growth.
Spec (may) Gene_expression (expression) of SSEA in skin associated with cicatrix and keloid scars
15) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.46 Pain Relevance 0
Accordingly, SabA-mediated adherence is positively correlated with sialyl-Lex concentration in vitro (Linden et al., 2004), and colonization density is increased in patients who produce high levels of sialyl-Lex, or are infected with SabA-positive strains of H. pylori (Sheu et al., 2006).
Gene_expression (produce) of Lex associated with sprains and strains
16) Confidence 0.58 Published 2008 Journal Microbiology Section Body Doc Link PMC2715451 Disease Relevance 0.57 Pain Relevance 0.10
H. pylori shows a tropism for areas of reduced acidity in the stomach that contain gastric pit cells producing sialyl-Lex (Bjorkholm & Salama, 2003), and studies have shown that clearance of infection reduces production of sialyl-Lex receptors to pre-infection levels (Mahdavi et al., 2002; Acheson & Luccioli, 2004; Roche et al., 2004).
Gene_expression (producing) of Lex in pit associated with infection
17) Confidence 0.58 Published 2008 Journal Microbiology Section Body Doc Link PMC2715451 Disease Relevance 0.43 Pain Relevance 0.04
Glycoconjugates bearing the sialyl-Lex antigen are rarely expressed in healthy gastric epithelial cells (Madrid et al., 1990), but they are upregulated during inflammation, and serve as binding sites for host cell adhesins of the selectin family (Alper, 2001).
Gene_expression (expressed) of Lex in epithelial cells associated with inflammation
18) Confidence 0.58 Published 2008 Journal Microbiology Section Body Doc Link PMC2715451 Disease Relevance 0.46 Pain Relevance 0.12
Unlike Lex antigens, Ley-related antigens were expressed in 32-77% of specimens of normal pancreas, with similar frequencies in specimens of chronic pancreatitis and pancreatic cancer.
Gene_expression (expressed) of Lex in pancreas associated with pancreatic cancer and chronic pancreatitis
19) Confidence 0.54 Published 1988 Journal Cancer Res. Section Abstract Doc Link 3335015 Disease Relevance 1.13 Pain Relevance 0.26
The Lex and Leg antigens are closely related carbohydrate antigens synthesized on type 2 blood group oligosaccharide side chains of glycolipids and glycoproteins.
Gene_expression (synthesized) of Lex in blood
20) Confidence 0.54 Published 1988 Journal Cancer Res. Section Abstract Doc Link 3335015 Disease Relevance 0.38 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox