INT242819

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 5.60
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Apc) plasma membrane (Apc) nucleus (Apc)
protein complex assembly (Apc) cytoplasm (Apc)
Anatomy Link Frequency
T cell 2
Apc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 97.40 Very High Very High Very High
cytokine 29 96.88 Very High Very High Very High
imagery 21 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
abdominal pain 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 458 100.00 Very High Very High Very High
Infection 55 99.88 Very High Very High Very High
INFLAMMATION 15 97.40 Very High Very High Very High
Apoptosis 3 95.80 Very High Very High Very High
Adhesions 3 95.36 Very High Very High Very High
Schistosomiasis 1 93.64 High High
Intestinal Cancer 4 93.16 High High
Worm Infection 4 91.76 High High
Polyps 70 88.48 High High
Disease 51 86.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We estimate that a mutation in the APC gene will be more severe then mutation in the MUTYH gene, as the APC gene is part of the Wnt pathway and can influence several cellular functions such as proliferation, differentiation, apoptosis, adhesion, migration, and chromosomal segregation.
Negative_regulation (severe) of Gene_expression (part) of APC gene associated with familial adenomatous polyposis, apoptosis and adhesions
1) Confidence 0.37 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0.96 Pain Relevance 0
As part of a multiprotein complex, the APC protein downregulates ?
Negative_regulation (downregulates) of Gene_expression (protein) of APC associated with familial adenomatous polyposis
2) Confidence 0.06 Published 2008 Journal Ann Surg Oncol Section Body Doc Link PMC2518080 Disease Relevance 1.83 Pain Relevance 0
Similarly, individuals with filarial infection have diminished expression of APC- and T cell-specific-TLR1, 2, 4, and 9 as well as decreased pro-inflammatory cytokine responses to TLR2, 4, and 9 ligands [3],[4].
Negative_regulation (diminished) of Gene_expression (expression) of APC in T cell associated with inflammation, infection and cytokine
3) Confidence 0.06 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 0.95 Pain Relevance 0.10
When APC function is lost, ?
Negative_regulation (lost) of Gene_expression (function) of APC associated with familial adenomatous polyposis
4) Confidence 0.05 Published 2008 Journal Ann Surg Oncol Section Body Doc Link PMC2518080 Disease Relevance 1.85 Pain Relevance 0

General Comments

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