INT242820

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Fap) extracellular space (Fap)
Anatomy Link Frequency
Thyroid 1
Fap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 109 100.00 Very High Very High Very High
Thyroid Neoplasm 13 99.80 Very High Very High Very High
Chromosomal Instability 1 98.80 Very High Very High Very High
Apoptosis 1 97.06 Very High Very High Very High
Intestinal Cancer 2 70.84 Quite High
Disease 11 64.04 Quite High
Hypertrophy 2 50.28 Quite High
Adenoma 10 49.08 Quite Low
Brain Tumor 17 48.04 Quite Low
Pancreatic Cancer 9 47.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin accumulates in the cytoplasm and binds to several transcription factors of the TCF/LEF, thereby altering the expression of various genes affecting proliferation, differentiation, migration and apoptosis of cells.13 In addition, APC stabilizes microtubules, leading to chromosomal stability.15,16 Inactivation of APC can lead to defective chromosome segregation and aberrant mitosis.17

FAP and Thyroid Carcinoma

Localization (segregation) of FAP in Thyroid associated with thyroid neoplasm, chromosomal instability, familial adenomatous polyposis and apoptosis
1) Confidence 0.20 Published 2008 Journal Ann Surg Oncol Section Body Doc Link PMC2518080 Disease Relevance 1.90 Pain Relevance 0

General Comments

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