INT24283

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Context Info
Confidence 0.30
First Reported 1988
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.06
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
external 2
reticulum 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 29 100.00 Very High Very High Very High
qutenza 11 99.82 Very High Very High Very High
tetrodotoxin 4 96.60 Very High Very High Very High
Calcium channel 5 92.52 High High
Inflammation 34 91.28 High High
agonist 14 84.24 Quite High
cytokine 9 76.08 Quite High
Analgesic 1 64.56 Quite High
Cannabinoid receptor 2 62.64 Quite High
fibrosis 3 55.04 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 12 100.00 Very High Very High Very High
Volume Depletion And Dehydration 40 99.84 Very High Very High Very High
Adhesions 15 98.88 Very High Very High Very High
Toxicity 3 95.96 Very High Very High Very High
INFLAMMATION 43 91.28 High High
Hepatocellular Cancer 3 88.92 High High
Death 2 87.28 High High
Pneumonia 3 86.72 High High
Stress 6 82.48 Quite High
Glioma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because hydration proceeded comparably in both conditions, Ca2+ activation of Pcat appears not to be much affected by dehydration, pH, or membrane potential, although subtle effects cannot be ruled out from these data.
Regulation (affected) of Positive_regulation (activation) of Ca2 associated with volume depletion and dehydration
1) Confidence 0.30 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0.25 Pain Relevance 0
We tested for the possible involvement of the IP3 receptor in the Echinacea-induction of intracellular Ca2+ release by evaluating the effect of 2-aminoethoxydiphenyl borate (2-APB), an IP3 receptor antagonist, on Echinacea-induced cytosolic Ca2+ increase.
Regulation (effect) of Positive_regulation (increase) of Ca2 associated with antagonist
2) Confidence 0.28 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.05
Two principal sources of Ca2+ affect the concentration of cytosolic Ca2+: internal Ca2+ stores, primarily in the endoplasmic reticulum (ER), and extracellular Ca2+.
Regulation (affect) of Positive_regulation (concentration) of Ca2 in reticulum
3) Confidence 0.28 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
2 integrin-induced Ca2+ influx seems dependent on the formation of InsP3 [39].
Spec (seems) Regulation (dependent) of Positive_regulation (induced) of Ca2
4) Confidence 0.23 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.44 Pain Relevance 0.04
Ca2+-regulated Rac activation
Regulation (regulated) of Positive_regulation (activation) of Ca2
5) Confidence 0.23 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.03
The capsaicin-induced increase in the intracellular Ca2+ and apoptosis were not significantly affected by the extracellular Ca2+ chelation with EGTA, whereas blockers of intracellular Ca2+ release (dantrolene) and phospholipase C inhibitors, U-73122 and manoalide, profoundly reduced the capsaicin effects.
Neg (not) Regulation (affected) of Positive_regulation (increase) of Ca2 associated with qutenza and apoptosis
6) Confidence 0.23 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 15742812 Disease Relevance 0.84 Pain Relevance 0.87
The experiment of Figure 5 shows the effect of increasing Ca2+ concentrations on the rehydration response.
Regulation (effect) of Positive_regulation (increasing) of Ca2
7) Confidence 0.22 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0 Pain Relevance 0
High [K+]o-induced Ca2+ accumulation was dependent on external Ca2+, but not on external Na+ ions ([Na]o), and was insensitive to both tetrodotoxin (3 microM) and tetraethylammonium (10 microM).
Neg (not) Regulation (dependent) of Positive_regulation (accumulation) of Ca2 in external associated with tetrodotoxin
8) Confidence 0.22 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2452233 Disease Relevance 0.33 Pain Relevance 0.51
Neither the simultaneous administration of Flupirtine with the apoptosis-inducing agent nor the preincubation of HUVEC with Flupirtine influenced the increase in the intracellular Ca2+ concentration [Ca2+]i caused by the production of ROS.
Neg (Neither) Regulation (influenced) of Positive_regulation (increase) of Ca2 associated with apoptosis
9) Confidence 0.21 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9973182 Disease Relevance 0.50 Pain Relevance 0.06
However, NADPH oxidase is also potentially involved in the activation of the Ca2+ pathway, and the potentialization of its activity may be accompanied by a risk of oxidant-mediated toxicity.


Regulation (involved) of Positive_regulation (activation) of Ca2 associated with toxicity
10) Confidence 0.14 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.70 Pain Relevance 0.15

General Comments

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