INT242880

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.24
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) RNA binding (SPI1) plasma membrane (TLR4)
intracellular (TLR4) nucleus (SPI1) cytoplasm (TLR4)
SPI1 (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 54 80.36 Quite High
ischemia 9 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 69 80.36 Quite High
Diabetes Mellitus 51 51.08 Quite High
Obesity 18 36.24 Quite Low
Insulin Resistance 30 35.28 Quite Low
Atherosclerosis 24 5.00 Very Low Very Low Very Low
Myocardial Infarction 12 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 9 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding of PU.1 to a specific and necessary motif (PU-12) on the TLR4 promoter in MNCs was suppressed by 24 ± 10% at 4 h following insulin infusion (P < 0.05) compared with baseline and control subjects (Fig. 3).
PU-12 Binding (binding) of TLR4
1) Confidence 0.03 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.05 Pain Relevance 0
The binding of PU.1 to a specific and necessary motif (PU-12) on the TLR4 promoter in MNCs was suppressed by 24 ± 10% at 4 h following insulin infusion (P < 0.05) compared with baseline and control subjects (Fig. 3).
PU.1 Binding (binding) of TLR4
2) Confidence 0.03 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.05 Pain Relevance 0
Our data also demonstrate clearly for the first time that insulin rapidly suppresses the DNA binding of PU.1 to a specific sequence of TLR4 gene promoter.
PU.1 Binding (binding) of TLR4
3) Confidence 0.03 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.13 Pain Relevance 0.07

General Comments

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