INT242881

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.13
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) RNA binding (SPI1) plasma membrane (TLR2)
intracellular (TLR2) nucleus (SPI1) cytoplasm (TLR2)
Anatomy Link Frequency
myeloid cell 2
SPI1 (Homo sapiens)
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 94.64 High High
ischemia 3 67.12 Quite High
Inflammatory response 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 23 94.64 High High
Diabetes Mellitus 17 92.52 High High
Systemic Lupus Erythematosus 1 88.36 High High
Autoimmune Disease 1 85.88 High High
Ventricular Remodeling 1 79.44 Quite High
Myocardial Infarction 4 73.32 Quite High
Insulin Resistance 10 73.28 Quite High
Cv Unclassified Under Development 3 67.12 Quite High
Injury 3 66.64 Quite High
Atherosclerosis 8 56.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PU.1 is a member of the ets gene family and is a master switch in the regulation of an array of genes involved in myeloid cell activation and differentiation, including TLR2, -4, and -9 (17,18).
PU.1 Negative_regulation (switch) of Regulation (regulation) of TLR2 in myeloid cell
1) Confidence 0.04 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 1.13 Pain Relevance 0.11

General Comments

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