INT242883

Context Info Confidence 0.17 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.35 Pain Relevance 0.60

small molecule metabolic process (INS) intracellular (TLR2) carbohydrate metabolic process (INS) cytoplasm (TLR2) cell-cell signaling (INS) signal transduction (TLR2)

INS (Homo sapiens) TLR2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 36 99.36 metalloproteinase 2 85.60 cytokine 2 84.40 ischemia 6 84.16 Inflammatory response 6 65.32 Inflammatory mediators 2 10.80 cINOD 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 46 99.36 Bacterial Infection 2 98.80 Endotoxemia 4 98.08 Infection 4 95.60 Rupture 2 91.44 Atherosclerosis 16 89.24 Cv Unclassified Under Development 6 84.16 Reperfusion Injury 2 83.44 Atherosclerotic Plaque 2 82.12 Shock 4 79.12

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The suppression of TLR2 expression at mRNA and protein level by insulin is relevant to gram-positive bacterial infections.

insulin Negative_regulation (suppression) of Gene_expression (expression) of TLR2 associated with bacterial infection

1) Confidence 0.17 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.94 Pain Relevance 0.36

The rapid suppression of TLR2 and TLR4 expression by insulin implies that insulin can be used clinically in endotoxemia and gram-negative (TLR4) and gram-positive (TLR2) infections to limit their inflammatory effects.

insulin Negative_regulation (suppression) of Gene_expression (expression) of TLR2 associated with endotoxemia, inflammation and infection

2) Confidence 0.13 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 1.41 Pain Relevance 0.24

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