INT242884

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
RNA binding (SPI1) nucleus (SPI1) carbohydrate metabolic process (INS)
INS (Homo sapiens)
SPI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 3 53.08 Quite High
Inflammation 18 49.60 Quite Low
ischemia 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 17 66.72 Quite High
Obesity 6 57.04 Quite High
INFLAMMATION 23 52.72 Quite High
Insulin Resistance 10 5.00 Very Low Very Low Very Low
Atherosclerosis 8 5.00 Very Low Very Low Very Low
Myocardial Infarction 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS—Insulin suppresses the expression of several TLRs at the transcriptional level, possibly through its suppressive effect on PU.1.



Insulin Spec (possibly) Regulation (effect) of PU.1
1) Confidence 0.03 Published 2008 Journal Diabetes Care Section Abstract Doc Link PMC2518353 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

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