INT242895

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR1) plasma membrane (TLR1) intracellular (TLR1)
Anatomy Link Frequency
plasma 2
monocytes 2
TLR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 34 90.88 High High
Inflammation 49 88.40 High High
chemokine 7 73.36 Quite High
Inflammatory response 15 31.44 Quite Low
Neuropeptide 1 6.80 Low Low
psoriasis 19 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 17 98.92 Very High Very High Very High
INFLAMMATION 66 88.40 High High
Injury 6 85.44 High High
Apoptosis 4 84.72 Quite High
Acne 11 81.56 Quite High
Adhesions 2 48.64 Quite Low
Skin Cancer 29 12.64 Low Low
Cancer 8 6.88 Low Low
Dermatitis 28 5.00 Very Low Very Low Very Low
Psoriasis 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunofluorescence studies of TLR1, 2, 3, 4 and 5 proteins in human corneal, limbal, and conjunctival tissues showed both plasma membrane and cytoplasmic localization of these proteins (Figure 2).
Negative_regulation (showed) of Gene_expression (studies) of TLR1 in plasma
1) Confidence 0.38 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
Insulin infusion suppressed the mRNA expression of TLR1, -2, -4, -7, and -9 in MNCs within 2 h, with a maximum fall at 4 h by 24 ± 9%, 21 ± 5%, 30 ± 8%, 28 ± 5%, and 27 ± 10%, respectively, below baseline (P < 0.05 for all) (Fig. 1).
Negative_regulation (suppressed) of Gene_expression (expression) of TLR1
2) Confidence 0.17 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.10 Pain Relevance 0
When primary human monocytes are treated with ATRA (all-trans retinoic acid), TLR 2 and CD14 are downregulated without any change in expression of TLR 1 and 4 [142].
Negative_regulation (downregulated) of Gene_expression (expression) of TLR 1 in monocytes
3) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.85 Pain Relevance 0.34

General Comments

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