INT242897

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.20
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.27
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MYD88) signal transduction (MYD88) plasma membrane (MYD88)
intracellular (MYD88) cytoplasm (MYD88)
MYD88 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 1 100.00 Very High Very High Very High
antagonist 2 88.24 High High
cytokine 48 71.04 Quite High
Inflammatory mediators 4 55.92 Quite High
Inflammatory response 18 49.60 Quite Low
agonist 54 46.16 Quite Low
Inflammation 84 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
ischemia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 103 100.00 Very High Very High Very High
Diabetes Mellitus 18 63.48 Quite High
Adhesions 8 53.44 Quite High
Injury 34 50.00 Quite Low
Stress 9 30.12 Quite Low
Obesity 13 20.08 Low Low
Shock 4 11.24 Low Low
Cirrhosis 61 5.00 Very Low Very Low Very Low
Fibrosis 24 5.00 Very Low Very Low Very Low
Insulin Resistance 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect is mediated through the TLR4-PI3K-AKT signaling pathway, as the induction of inflammatory markers was also inhibited by a dominant-negative mutant of TLR4, MyD88, IRAK-1, TRAF6 or I?
Positive_regulation (mediated) of Gene_expression (mutant) of MyD88 associated with inflammatory marker
1) Confidence 0.20 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.21 Pain Relevance 0.19
MyD88 and CD14 are essential proteins involved in TLR signal transduction and LPS binding; therefore, their expression following insulin infusion was also investigated.
Positive_regulation (following) of Gene_expression (expression) of MyD88
2) Confidence 0.13 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox