INT2429

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 128
Total Number 128
Disease Relevance 93.76
Pain Relevance 39.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) aging (Mpo)
Anatomy Link Frequency
neutrophil 17
plasma 5
MPO 4
paw 3
myocardium 2
Mpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 879 100.00 Very High Very High Very High
ischemia 261 100.00 Very High Very High Very High
aspirin 48 100.00 Very High Very High Very High
Morphine 103 99.98 Very High Very High Very High
cINOD 67 99.98 Very High Very High Very High
qutenza 50 99.98 Very High Very High Very High
cytokine 214 99.96 Very High Very High Very High
Paracetamol 28 99.90 Very High Very High Very High
vincristine 19 99.84 Very High Very High Very High
Angina 5 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1002 100.00 Very High Very High Very High
Urological Neuroanatomy 623 100.00 Very High Very High Very High
Stress 296 100.00 Very High Very High Very High
Cv Unclassified Under Development 229 100.00 Very High Very High Very High
Pressure And Volume Under Development 106 100.00 Very High Very High Very High
Reperfusion Injury 50 100.00 Very High Very High Very High
Burns 34 100.00 Very High Very High Very High
Hypoxia 18 100.00 Very High Very High Very High
Myelodysplastic Syndromes 5 100.00 Very High Very High Very High
Neutrophil Disorders 1 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 6-OHDA pretreated rats, lidocaine administration reduced the macroscopic and histological scores and MPO activity almost to control levels.
Negative_regulation (reduced) of MPO associated with urological neuroanatomy and lidocaine
1) Confidence 0.59 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9124351 Disease Relevance 0.74 Pain Relevance 0.99
During the ischemic period before reperfusion, the ischemic leg showed a significant decrease in MPO activity.
Negative_regulation (decrease) of MPO in leg associated with urological neuroanatomy
2) Confidence 0.59 Published 1990 Journal Int J Microcirc Clin Exp Section Abstract Doc Link 2158941 Disease Relevance 1.03 Pain Relevance 0.29
Gastric LPO and MPO activity that were increased significantly by ASA were decreased after treatment with omeprazole, famotidine, and melatonin.
Negative_regulation (decreased) of MPO associated with aspirin and urological neuroanatomy
3) Confidence 0.59 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11281181 Disease Relevance 0.46 Pain Relevance 0.43
In the myeloperoxidase (MPO) assay, 300 mg kg (-1) crude extract produced a significant inhibition of the MPO activity, at 6 h and 24 h after injection of carrageenan, by 42.8 and 46.2%, respectively.
Negative_regulation (inhibition) of MPO associated with urological neuroanatomy
4) Confidence 0.59 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17430644 Disease Relevance 0.54 Pain Relevance 0.26
The hydroalcoholic extract (200 mg/kg) substantially reduced MPO activity (P < 0.05), which was increased in the control group.
Negative_regulation (reduced) of MPO associated with urological neuroanatomy
5) Confidence 0.59 Published 2001 Journal J Ethnopharmacol Section Abstract Doc Link 11297854 Disease Relevance 0.89 Pain Relevance 0.32
Moreover, the decrease in MPO content along with a reduced number in tissue cells by celecoxib suggests a more selective anti-inflammatory effect in this model than that shown by morphine, as discussed below.
Negative_regulation (decrease) of MPO associated with inflammation, urological neuroanatomy and morphine
6) Confidence 0.59 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2804053 Disease Relevance 1.01 Pain Relevance 0.79
Our data are in line with other studies, which showed that morphine reduced both the MPO activity and the number of neutrophils, using an immunohistochemistry technique [25].
Negative_regulation (reduced) of MPO in neutrophils associated with urological neuroanatomy and morphine
7) Confidence 0.59 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2804053 Disease Relevance 0.49 Pain Relevance 0.73
After the induction of colitis, daily intracolonic treatment with ropivacaine for 1 week reduced morphological damage and myeloperoxidase activity.
Negative_regulation (reduced) of myeloperoxidase associated with colitis
8) Confidence 0.59 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525083 Disease Relevance 0.33 Pain Relevance 0.07
VCR degradation was significantly increased by adding hydrogen peroxide, an electron donor for MPO, to the sera and was almost completely inhibited by adding 1 mM acetaminophen, an inhibitor of MPO.
Negative_regulation (inhibitor) of MPO associated with vincristine, paracetamol and urological neuroanatomy
9) Confidence 0.59 Published 1996 Journal Leuk. Lymphoma Section Abstract Doc Link 8833400 Disease Relevance 0.91 Pain Relevance 0.47
We found that NSAIDs inhibited both the peroxidation and chlorinating activity of MPO as follows: diclofenac (36 +/- 10, 45 +/- 3%), indomethacin (97 +/- 2, 100 +/- 1%), naproxen (56 +/- 8, 76 +/- 3%), piroxicam (77 +/- 5, 99 +/- 1%), and tenoxicam (90 +/- 2, 100 +/- 1%), respectively (N = 3).
Negative_regulation (inhibited) of MPO associated with cinod, urological neuroanatomy and diclofenac
10) Confidence 0.59 Published 2005 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 15962179 Disease Relevance 0.49 Pain Relevance 0.76
Treatment of rats with NAC significantly elevated the reduced GSH levels while decreasing MDA levels and MPO activity.
Negative_regulation (decreasing) of MPO associated with urological neuroanatomy
11) Confidence 0.59 Published 2004 Journal Burns Section Abstract Doc Link 15555789 Disease Relevance 1.41 Pain Relevance 0.07
HCl-induced lesions, MPO activity, TBARS, and plasma NOx production were decreased by AG.
Negative_regulation (decreased) of MPO in plasma associated with urological neuroanatomy
12) Confidence 0.59 Published 2001 Journal J. Lab. Clin. Med. Section Abstract Doc Link 11574821 Disease Relevance 1.13 Pain Relevance 0
Ketamine only at a dose of 50 mg/kg inhibited TNF-alpha and IL-6 production, and decreased MPO activity and wet/dry weight ratio after endotoxin challenge.
Negative_regulation (decreased) of MPO
13) Confidence 0.58 Published 2005 Journal Inflamm. Res. Section Body Doc Link 15883747 Disease Relevance 0.06 Pain Relevance 0
Secondly, we screened an array of compounds that are in current clinical use for their ability to inhibit MPO.
Negative_regulation (inhibit) of MPO associated with urological neuroanatomy
14) Confidence 0.58 Published 1994 Journal Leukemia Section Abstract Doc Link 8152263 Disease Relevance 0.59 Pain Relevance 0.30
Acetaminophen, N-acetylcysteine, propylthiouracil, D-penicillamine, mefenamic acid, dapsone, and methimazole all inhibited MPO at clinically achievable concentrations.
Negative_regulation (inhibited) of MPO associated with paracetamol and urological neuroanatomy
15) Confidence 0.58 Published 1994 Journal Leukemia Section Abstract Doc Link 8152263 Disease Relevance 0.61 Pain Relevance 0.28
Infarct size restriction was paralleled by reduction of both cardiac MPO and plasma CK.
Negative_regulation (reduction) of MPO in plasma associated with urological neuroanatomy
16) Confidence 0.58 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 16488624 Disease Relevance 0.57 Pain Relevance 0.11
Anti-NGF significantly blunted the development of hyperalgesia and led to a decrease in gastric wall thickness and MPO activity.
Negative_regulation (decrease) of MPO associated with hyperalgesia, nerve growth factor and urological neuroanatomy
17) Confidence 0.58 Published 2003 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 12846723 Disease Relevance 1.08 Pain Relevance 0.80
Repeated stress insults reduced stress-induced gastric damage, NO production and MPO activity, with an increase in PGE2 and CGRP levels compared with rats exposed to single cold restraint stress.
Negative_regulation (reduced) of MPO associated with stress, urological neuroanatomy and calcitonin gene-related peptide
18) Confidence 0.58 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 17002672 Disease Relevance 1.07 Pain Relevance 0.54
There was also a significant transcoronary reduction in myeloperoxidase content in both groups with unstable angina.
Negative_regulation (reduction) of myeloperoxidase
19) Confidence 0.57 Published 2002 Journal N. Engl. J. Med. Section Body Doc Link 12097534 Disease Relevance 0 Pain Relevance 0
Increased flap viability was correlated with a reduction in myeloperoxidase content in the propofol group compared with control operated animals, with minor variations observed in the different flap regions and time points tested.
Negative_regulation (reduction) of myeloperoxidase
20) Confidence 0.57 Published 2004 Journal Ann Plast Surg Section Abstract Doc Link 15480016 Disease Relevance 0.06 Pain Relevance 0.58

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