INT242902

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 9.34
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NCF1) cytosol (NCF1) GTPase activity (NCF1)
cytoplasm (NCF1)
Anatomy Link Frequency
macrophages 1
leukocyte 1
T cell 1
mononuclear cells 1
NCF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 43 97.88 Very High Very High Very High
Multiple sclerosis 256 95.68 Very High Very High Very High
Inflammation 43 95.52 Very High Very High Very High
Neuritis 8 88.28 High High
Central nervous system 8 80.84 Quite High
Crohn's disease 8 77.60 Quite High
Demyelination 10 45.48 Quite Low
ischemia 13 20.40 Low Low
depression 3 11.92 Low Low
Hippocampus 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 21 99.98 Very High Very High Very High
Autoimmune Disease 105 97.92 Very High Very High Very High
Neutrophil Disorders 41 97.90 Very High Very High Very High
Arthritis 43 97.88 Very High Very High Very High
Metastasis 32 96.04 Very High Very High Very High
Demyelinating Disease 274 95.68 Very High Very High Very High
INFLAMMATION 42 95.52 Very High Very High Very High
Urological Neuroanatomy 9 95.40 Very High Very High Very High
Malaria 192 92.00 High High
Disease 208 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently it was shown that transgenic expression of ncf1 in macrophages can suppress autoimmune T cell responses in mice [14].
Gene_expression (expression) of ncf1 in macrophages associated with targeted disruption
1) Confidence 0.78 Published 2008 Journal Malar J Section Body Doc Link PMC2635379 Disease Relevance 1.46 Pain Relevance 0.27
GT/GTGT ratio has functional significance in terms of individual NCF1 expression, ROI production or susceptibility to infectious or autoimmune diseases is currently unknown.
Gene_expression (expression) of NCF1 associated with autoimmune disease
2) Confidence 0.78 Published 2008 Journal Malar J Section Body Doc Link PMC2635379 Disease Relevance 0.60 Pain Relevance 0.07
B) binding, reactive oxygen species generation, and p47phox expression by mononuclear cells (MNCs) (1,2) in humans.
Gene_expression (expression) of p47phox in mononuclear cells
3) Confidence 0.75 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.32 Pain Relevance 0.05
Unlike the heterogeneous CGD-causing mutations in other leukocyte NADPH oxidase subunits, about 95% of the cases are attributed to a NCF1 mutation carry a common dinucleotide deletion (?
Gene_expression (mutation) of NCF1 in leukocyte associated with neutrophil disorders
4) Confidence 0.67 Published 2008 Journal Malar J Section Body Doc Link PMC2635379 Disease Relevance 1.35 Pain Relevance 0.23
NCF1 genes per NCF1 gene), seven with a ratio of 1:1 (reflecting heterozygosity for a haplotype containing each one type I and type II ?
Gene_expression (gene) of NCF1
5) Confidence 0.67 Published 2008 Journal Malar J Section Body Doc Link PMC2635379 Disease Relevance 0.51 Pain Relevance 0.03
However, one limitation of this study is that only moderate numbers of patients were included, which allows only to exclude NCF1 ?
Gene_expression (exclude) of NCF1
6) Confidence 0.67 Published 2008 Journal Malar J Section Body Doc Link PMC2635379 Disease Relevance 1.65 Pain Relevance 0.42
NCF1 genes per NCF1 gene), seven with a ratio of 1:1 (reflecting heterozygosity for a haplotype containing each one type I and type II ?
Gene_expression (gene) of NCF1
7) Confidence 0.67 Published 2008 Journal Malar J Section Body Doc Link PMC2635379 Disease Relevance 0.51 Pain Relevance 0.03
1:1 could lead to enhanced expression of NCF1 and subsequently to higher ROI production which could in turn modulate T cell responses.
Gene_expression (expression) of NCF1 in T cell
8) Confidence 0.67 Published 2008 Journal Malar J Section Body Doc Link PMC2635379 Disease Relevance 0.96 Pain Relevance 0.22
If this effect on p47phox expression in turn may determine oxidative burst is currently unclear.
Gene_expression (expression) of p47phox
9) Confidence 0.60 Published 2008 Journal Malar J Section Body Doc Link PMC2635379 Disease Relevance 0.84 Pain Relevance 0.04
As Fig. 6b demonstrates, massive reduction in Hv1 level does not prevent high-level expression of the phox subunits Nox2, p22phox and p47phox.


Gene_expression (expression) of p47phox
10) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.16 Pain Relevance 0
Longitudinal data tracking the NCF of patients receiving WBRT, SRS, or both are sparse.
Gene_expression (tracking) of NCF
11) Confidence 0.17 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2910483 Disease Relevance 0.49 Pain Relevance 0
for the function of p47phox, and thiol oxidizing agents have been shown to
Gene_expression (function) of p47phox
12) Confidence 0.13 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.49 Pain Relevance 0.03

General Comments

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