INT24291

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Context Info
Confidence 0.61
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.67
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
plasma 2
sensory neurons 2
nerves 2
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 17 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
hypoalgesia 1 99.90 Very High Very High Very High
substance P 4 99.76 Very High Very High Very High
qutenza 9 99.72 Very High Very High Very High
Nerve growth factor 8 94.88 High High
Hyperalgesia 1 91.12 High High
Lasting pain 2 90.16 High High
Inflammation 3 86.96 High High
Pain 2 68.32 Quite High
Disease Link Frequency Relevance Heat
Hypoalagesia 1 99.90 Very High Very High Very High
Hyperalgesia 1 91.12 High High
Pain 3 90.16 High High
INFLAMMATION 2 86.96 High High
Hypertension 2 79.52 Quite High
Nociception 1 78.24 Quite High
Aging 2 74.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic capsaicin pretreatment induced a marked loss of the CGRP- and SP-immunoreactive (-IR) nerves in the lower airways.
Positive_regulation (induced) of Negative_regulation (loss) of CGRP in nerves associated with qutenza, substance p and calcitonin gene-related peptide
1) Confidence 0.61 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 2452458 Disease Relevance 0 Pain Relevance 0.96
We show that administration of trkA-IgG produces a sustained thermal and chemical hypoalgesia and leads to a downregulation of the sensory neuropeptide CGRP (calcitonin gene-related peptide) in treated sensory neurons.
Positive_regulation (leads) of Negative_regulation (downregulation) of CGRP in sensory neurons associated with neuropeptide, hypoalgesia and calcitonin gene-related peptide
2) Confidence 0.45 Published 1995 Journal Nat. Med. Section Abstract Doc Link 7585179 Disease Relevance 0.52 Pain Relevance 0.95
The results showed that the number of circulating senescent EPCs was significantly increased in hypertension concomitantly with the decreased plasma level of CGRP and the decreased CGRP mRNA expression in EPCs.
Positive_regulation (increased) of Negative_regulation (decreased) of CGRP in plasma
3) Confidence 0.44 Published 2010 Journal J. Hypertens. Section Body Doc Link 20375903 Disease Relevance 0.15 Pain Relevance 0

General Comments

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