INT242946

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE1B) signal transduction (PDE1B) nucleolus (PDE1B)
nucleus (PDE1B) cytoplasm (PDE1B)
PDE1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 14 63.84 Quite High
Central nervous system 26 55.08 Quite High
long-term potentiation 34 5.00 Very Low Very Low Very Low
Hippocampus 18 5.00 Very Low Very Low Very Low
Multiple sclerosis 14 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 20 55.76 Quite High
Pressure And Volume Under Development 14 52.48 Quite High
Neurological Disease 8 34.32 Quite Low
Neurodegenerative Disease 40 5.00 Very Low Very Low Very Low
Disease 40 5.00 Very Low Very Low Very Low
Demyelinating Disease 14 5.00 Very Low Very Low Very Low
Cognitive Disorder 12 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Stroke 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example many effects of Ca2+ on cAMP and cGMP are mediated by the activation of the Ca2+-Calmodulin (Ca2+-CaM) dependent phosphorylation of PDEs (Sonnenburg et al 1995).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of PDEs
1) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0.11 Pain Relevance 0.09
For example many effects of Ca2+ on cAMP and cGMP are mediated by the activation of the Ca2+-Calmodulin (Ca2+-CaM) dependent phosphorylation of PDEs (Sonnenburg et al 1995).
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of PDEs
2) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0.11 Pain Relevance 0.08

General Comments

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