INT24296

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2003
Negated 1
Speculated 1
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 2.03
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NPY) extracellular space (NPY) extracellular region (NPY)
cell (NPY)
Anatomy Link Frequency
nerve 2
central nervous system 1
NPY (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 36 100.00 Very High Very High Very High
Enkephalin 13 100.00 Very High Very High Very High
bradykinin 5 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
Somatostatin 18 99.92 Very High Very High Very High
Calcitonin gene-related peptide 6 99.92 Very High Very High Very High
opiate 3 99.84 Very High Very High Very High
noradrenaline 5 99.76 Very High Very High Very High
substance P 8 99.36 Very High Very High Very High
Central nervous system 3 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 13 99.36 Very High Very High Very High
Dementia 1 98.82 Very High Very High Very High
INFLAMMATION 1 97.76 Very High Very High Very High
Encephalopathy 3 93.68 High High
Aggression 2 86.88 High High
Disease 2 80.40 Quite High
Catalepsy 1 79.60 Quite High
Convulsion 2 76.96 Quite High
Death 1 75.36 Quite High
Increased Venous Pressure Under Development 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that NPY interacts with NA during sympathetic nerve activation primarily through a presynaptic effect.
NPY Binding (interacts) of in nerve associated with noradrenaline
1) Confidence 0.48 Published 1986 Journal J Auton Pharmacol Section Abstract Doc Link 3755439 Disease Relevance 0.07 Pain Relevance 0.38
The nerve fibers that supply the external muscle of the human gastrointestinal tract were examined for their immunoreactivity to the neuropeptides enkephalin, neuropeptide Y, somatostatin, substance P, and vasoactive intestinal peptide, for tyrosine hydroxylase (a catecholamine-synthesizing enzyme), and for coexistence between immunoreactivities in nerve fibers.
neuropeptide Y Spec (examined) Binding (immunoreactivity) of in nerve associated with catecholamine, somatostatin, neuropeptide, enkephalin and substance p
2) Confidence 0.36 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2453391 Disease Relevance 0 Pain Relevance 0.52
The list of peptides includes, but is not limited to: ACTH, angiotensin, bombesin, bradykinin, calcitonin, casomorphin, CCK, ceruletide, CGRP, CRF, dermorphin, DSIP, dynorphin, endorphins, enkephalins, GRF, gastrin, LHRH, litorin, metkephamid, MIF-l, motilin, MSH, NPY, NT, oxytocin, ranatensin, sauvagine, substances P and K, somatostatin, TRH, VIP, vasopressin, and vasotocin.
NPY Binding (limited) of associated with dynorphin, somatostatin, enkephalin and bradykinin
3) Confidence 0.36 Published 1986 Journal Peptides Section Abstract Doc Link 3534808 Disease Relevance 0.31 Pain Relevance 0.50
Inflammatory disorders of the central nervous system and dementia due to other causes in HIV-seronegative patients were not associated with increased CSF NPY-LI.
NPY Binding (associated) of in central nervous system associated with dementia, inflammation, acquired immune deficiency syndrome or hiv infection and central nervous system
4) Confidence 0.35 Published 1996 Journal J. Neurol. Sci. Section Abstract Doc Link 8815163 Disease Relevance 1.13 Pain Relevance 0.40
Synthesis and binding affinity of neuropeptide Y at opiate receptors.
neuropeptide Y Binding (affinity) of associated with neuropeptide and opiate
5) Confidence 0.35 Published 2003 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 12643904 Disease Relevance 0 Pain Relevance 0.52
GPR73 is related to the neuropeptide Y (NPY) receptor NY2R which mainly binds the pancreatic peptide YY of 36 amino acids, and these two are placed together on a branch distinct from the NPY receptors NY4R and NY1R.
NPY Binding (binds) of associated with neuropeptide
6) Confidence 0.24 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.08
SO demonstrated immunoreactivity for VIP, PHI (PHM), neuropeptide Y, CGRP, galanin, somatostatin, substance P, and enkephalin, but no immunoreactivity was observed for bombesin.
neuropeptide Y Binding (immunoreactivity) of associated with somatostatin, neuropeptide, enkephalin, substance p and calcitonin gene-related peptide
7) Confidence 0.22 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 8313811 Disease Relevance 0.51 Pain Relevance 0.79
GPR72 does not bind a NPY ligand [49].
NPY Neg (not) Binding (bind) of
8) Confidence 0.21 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.04

General Comments

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