INT242974

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.39
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapk8, Esr1) nucleus (Mapk8, Esr1) mitochondrion (Mapk8)
enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
Mapk8 (Mus musculus)
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 97.48 Very High Very High Very High
cytokine 2 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 31 100.00 Very High Very High Very High
Obesity 47 99.20 Very High Very High Very High
Insulin Resistance 9 98.44 Very High Very High Very High
INFLAMMATION 5 97.48 Very High Very High Very High
Cancer 6 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Metastasis 1 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As JNK can inhibit insulin action and activate proinflammatory pathways, ER stress activation of JNK may be a link between obesity, insulin resistance, and inflammation.



JNK Negative_regulation (inhibit) of Positive_regulation (activation) of ER associated with stress, inflammation, obesity and insulin resistance
1) Confidence 0.01 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2518495 Disease Relevance 1.39 Pain Relevance 0.05

General Comments

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