INT242987

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 7.04
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
alveolar macrophages 4
epithelial cells 3
respiratory 1
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 146 100.00 Very High Very High Very High
Inflammation 98 100.00 Very High Very High Very High
agonist 4 28.96 Quite Low
cytokine 104 21.04 Low Low
Inflammatory response 6 18.16 Low Low
chemokine 32 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 112 100.00 Very High Very High Very High
INFLAMMATION 74 100.00 Very High Very High Very High
Diabetes Mellitus 8 99.24 Very High Very High Very High
Melioidosis 228 96.12 Very High Very High Very High
Myocardial Infarction 12 95.96 Very High Very High Very High
Infection 164 93.84 High High
Pneumonia 36 90.44 High High
Natriuresis 6 88.24 High High
Fibrosis 36 86.88 High High
Coronary Heart Disease 56 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using this model we confirmed increased release of OPN in the circulation and the lungs in mice and identified alveolar macrophages and respiratory epithelial cells as potential cellular sources for OPN upon infection with B. pseudomallei.
Positive_regulation (increased) of Localization (release) of OPN in alveolar macrophages associated with infection
1) Confidence 0.60 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.04 Pain Relevance 0
OPN release by both alveolar macrophages and epithelial cells was significantly enhanced upon B. pseudomallei stimulation in a dose dependent manner compared to the medium control (MHS: P<0.05 for both MOI, MLE-15: P?
Positive_regulation (enhanced) of Localization (release) of OPN in epithelial cells
2) Confidence 0.43 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 0.70 Pain Relevance 0
We have shown that osteopontin (OPN), a secreted inflammatory glycophosphoprotein, plays a pivotal role in cardiac fibrosis (11) and is often increased in the tissues of diabetic mouse models (11–13).
Positive_regulation (increased) of Localization (secreted) of osteopontin associated with fibrosis, inflammation, diabetes mellitus and cardiovascular disorder under development
3) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.79 Pain Relevance 0.30
We have shown that osteopontin (OPN), a secreted inflammatory glycophosphoprotein, plays a pivotal role in cardiac fibrosis (11) and is often increased in the tissues of diabetic mouse models (11–13).
Positive_regulation (increased) of Localization (secreted) of OPN associated with fibrosis, inflammation, diabetes mellitus and cardiovascular disorder under development
4) Confidence 0.31 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.78 Pain Relevance 0.30
Using this model we confirmed increased release of OPN in the circulation and the lungs in mice and identified alveolar macrophages and respiratory epithelial cells as potential cellular sources for OPN upon infection with B. pseudomallei.
Positive_regulation (increased) of in respiratory Localization (release) of OPN in alveolar macrophages associated with infection
5) Confidence 0.20 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.04 Pain Relevance 0
OPN release by both alveolar macrophages and epithelial cells was significantly enhanced upon B. pseudomallei stimulation in a dose dependent manner compared to the medium control (MHS: P<0.05 for both MOI, MLE-15: P?
Positive_regulation (enhanced) of in alveolar macrophages Localization (release) of OPN in epithelial cells
6) Confidence 0.15 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 0.70 Pain Relevance 0

General Comments

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