INT242988

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.28
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
osteoblast 2
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 75 95.36 Very High Very High Very High
cytokine 24 93.12 High High
chemokine 8 90.32 High High
Inflammation 96 83.08 Quite High
antagonist 7 18.84 Low Low
Versed 1 14.84 Low Low
Bile 39 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 7 100.00 Very High Very High Very High
Osteogenic Sarcomas 5 99.86 Very High Very High Very High
Hyperoxia 98 99.68 Very High Very High Very High
Cardiovascular Disorder Under Development 56 95.36 Very High Very High Very High
Stress 7 93.08 High High
Coronary Heart Disease 28 91.56 High High
INFLAMMATION 87 83.08 Quite High
Fibrosis 18 79.96 Quite High
Targeted Disruption 31 76.48 Quite High
Diabetes Mellitus 7 72.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AMCMs had more than a fivefold increase in OPN mRNA expression versus cPPAR?
Positive_regulation (increase) of Transcription (expression) of OPN
1) Confidence 0.28 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.22 Pain Relevance 0.36
Vitamin K2 treatment of osteosarcoma cells increased mRNA levels for the osteoblast markers bone alkaline phosphatase, osteoprotegerin, osteopontin and matrix Gla protein.
Positive_regulation (increased) of Transcription (levels) of osteopontin in osteoblast associated with osteoporosis and osteogenic sarcomas
2) Confidence 0.08 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.69 Pain Relevance 0
On day 6 of life, hyperoxia induced a huge increase in the protein and mRNA concentrations of IL6, MCP-1, and OPN (Figures 2–3, p<0.05 to p<0.01 by Mann-Whitney U test depending of the parameter).
Positive_regulation (increase) of Transcription (concentrations) of OPN associated with hyperoxia
3) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.68 Pain Relevance 0.28
On day 6 of life, hyperoxia induced a huge increase in the protein and mRNA concentrations of IL6, MCP-1, and OPN (Figures 2–3, p<0.05 to p<0.01 by Mann-Whitney U test depending of the parameter).
Positive_regulation (increase) of Transcription (concentrations) of OPN associated with hyperoxia
4) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.68 Pain Relevance 0.28

General Comments

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