INT243017

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
adult brain 2
raphe nucleus 2
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 202 99.96 Very High Very High Very High
Raphe 14 99.12 Very High Very High Very High
sSRI 98 85.36 High High
Serotonin 34 84.28 Quite High
depression 22 56.08 Quite High
antidepressant 10 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
tricyclic antidepressant 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 24 56.08 Quite High
Anxiety Disorder 34 54.80 Quite High
Aging 4 54.12 Quite High
Coronary Heart Disease 4 50.00 Quite Low
Dilated Cardiomyopathy 16 23.12 Low Low
Congenital Anomalies 10 7.92 Low Low
Body Weight 14 5.00 Very Low Very Low Very Low
Heart Rate Under Development 10 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Eating Disorder 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the decreased 5-HTT levels in the raphe nucleus after prenatal fluoxetine treatment (0.8 mg/kg/day) are dose-dependent, autoradiography using [N-methyl-3H]-citalopram was performed on adult brain tissue of mice prenatally exposed to different concentrations of fluoxetine (0.3, 0.6 and 0.8 mg/kg/day; Fig. 6). 5-HTT binding was significantly decreased in the offspring exposed to 0.8 (N?
Negative_regulation (decreased) of 5-HTT Binding (binding) of in adult brain associated with raphe and fluoxetine
1) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518512 Disease Relevance 0.11 Pain Relevance 1.09
After prenatal exposure to fluoxetine, 5-HTT binding decreased significantly in the raphe nucleus at P20 (40%; N?
Negative_regulation (decreased) of 5-HTT Binding (binding) of in raphe nucleus associated with raphe and fluoxetine
2) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518512 Disease Relevance 0.11 Pain Relevance 0.80

General Comments

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