INT243033

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.59
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp8) extracellular space (Mmp8) extracellular region (Mmp8)
proteinaceous extracellular matrix (Mmp8)
Anatomy Link Frequency
lung 3
amniotic fluid 2
neutrophil 2
Mmp8 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 589 100.00 Very High Very High Very High
Inflammation 185 98.20 Very High Very High Very High
Inflammatory response 20 89.88 High High
Inflammatory stimuli 3 88.12 High High
cytokine 53 74.48 Quite High
fibrosis 69 55.16 Quite High
anesthesia 1 18.64 Low Low
Inflammatory mediators 18 5.00 Very Low Very Low Very Low
antagonist 18 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Premature Birth 80 99.40 Very High Very High Very High
Infection 108 98.40 Very High Very High Very High
INFLAMMATION 193 98.20 Very High Very High Very High
Pulmonary Disease 191 97.72 Very High Very High Very High
Rupture 12 95.92 Very High Very High Very High
Bacterial Infection 23 92.24 High High
Pneumonia 184 83.36 Quite High
Nosocomial And Community Acquired Bacterial Infections 3 82.24 Quite High
Apoptosis 29 73.44 Quite High
Targeted Disruption 34 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantification of MMP-8 by western blot
Localization (Quantification) of MMP-8
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.23 Pain Relevance 0.11
Attracted to the lung by IL-8 and leukrotrien B4 PMN secrete MMP-8 and MMP-9.
Localization (secrete) of MMP-8 in lung associated with metalloproteinase
2) Confidence 0.19 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.66 Pain Relevance 0.83
MMP-8 (neutrophil Collagenase) and MMP-9 (Gelatinase 2) are synthesized and stored in PMN [6].
Localization (stored) of neutrophil Collagenase in neutrophil associated with metalloproteinase
3) Confidence 0.18 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.83 Pain Relevance 0.52
MMP-8 (neutrophil Collagenase) and MMP-9 (Gelatinase 2) are synthesized and stored in PMN [6].
Localization (stored) of MMP-8 in neutrophil associated with metalloproteinase
4) Confidence 0.18 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.83 Pain Relevance 0.52
An increase in midtrimester concentrations of amniotic fluid MMP-8, IL-6, and angiogenin are risk factors for early spontaneous preterm delivery (<32 weeks).
Localization (concentrations) of MMP-8 in amniotic fluid associated with premature birth
5) Confidence 0.15 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.58 Pain Relevance 0.16
MMP-8 is released during neutrophil activation, and amniotic fluid concentrations are elevated both in patients with intraamniotic infection and in patients with negative amniotic fluid cultures who deliver preterm.
Localization (released) of MMP-8 in amniotic fluid associated with infection
6) Confidence 0.14 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.59 Pain Relevance 0.10
Active forms of NE, MMP-8, and MMP-9 released from these cells are detectable in lung secretions from COPD patients (Burnett et al 1987; Yoshioka et al 1995; Betsuyaku et al 1999; Hill et al 1999).
Localization (released) of MMP-8 in lung associated with pulmonary disease
7) Confidence 0.11 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.94 Pain Relevance 0.14
Active forms of NE, MMP-8, and MMP-9 released from these cells are detectable in lung secretions from COPD patients (Burnett et al 1987; Yoshioka et al 1995; Betsuyaku et al 1999; Hill et al 1999).
Localization (released) of MMP-8 in lung associated with pulmonary disease
8) Confidence 0.10 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.94 Pain Relevance 0.14

General Comments

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