INT243034

Context Info Confidence 0.04 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 4.07 Pain Relevance 2.52

nucleus (Rarb) DNA binding (Rarb)

Anatomy Link Frequency molar 1 Rarb (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 612 100.00 Inflammation 44 94.68 Inflammatory response 4 73.12 cytokine 16 42.24 imagery 4 38.28 fibrosis 8 32.32 Inflammatory marker 8 5.00 Inflammatory stimuli 4 5.00 lidocaine 4 5.00 Versed 4 5.00

Disease Link Frequency Relevance Heat Pneumonia 192 100.00 Infection 48 97.60 Bacterial Infection 28 97.24 INFLAMMATION 56 94.68 Pulmonary Disease 20 76.24 Cancer 4 74.20 Gastrointestinal Disease 4 73.24 Sprains And Strains 4 72.16 Diabetes Mellitus 4 71.76 Injury 8 71.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MMP activation in HAP might be necessary for bacterial clearance, but unresolved infection might trigger ongoing MMP activation and tissue destruction[26,27].

Positive_regulation (activation) of HAP associated with metalloproteinase, pneumonia and infection

1) Confidence 0.04 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.33 Pain Relevance 0.55

Low MMP increment and activation in HAP-patients with low-risk bacteria might be explained by less virulence of these bacteria.

Positive_regulation (activation) of HAP associated with metalloproteinase and pneumonia

2) Confidence 0.04 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.86 Pain Relevance 0.60

The molar MMP-9/TIMP-1 ratio and the gelatinolytic activity of MMP-9 was increased in HAP patients compared to controls (MMP-9/TIMP-1 ratio 0.43 (± 0.12) vs. 0.04 (± 0.02), p < 0.0001; MMP-9 activity 149 (± 41) vs. 34 (± 11), p = 0.0001).

Positive_regulation (increased) of HAP in molar associated with metalloproteinase and pneumonia

3) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.94 Pain Relevance 0.60

Hartog et al. found increased activated pulmonary MMP in hospital-acquired pneumonia (HAP) with some evidence of increased MMP levels in patients with proven bacterial infection [8].

Positive_regulation (activated) of HAP associated with metalloproteinase, pneumonia and bacterial infection

4) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.94 Pain Relevance 0.77

General Comments

This test has worked.