INT243034

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.07
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rarb) DNA binding (Rarb)
Anatomy Link Frequency
molar 1
Rarb (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 612 100.00 Very High Very High Very High
Inflammation 44 94.68 High High
Inflammatory response 4 73.12 Quite High
cytokine 16 42.24 Quite Low
imagery 4 38.28 Quite Low
fibrosis 8 32.32 Quite Low
Inflammatory marker 8 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
lidocaine 4 5.00 Very Low Very Low Very Low
Versed 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pneumonia 192 100.00 Very High Very High Very High
Infection 48 97.60 Very High Very High Very High
Bacterial Infection 28 97.24 Very High Very High Very High
INFLAMMATION 56 94.68 High High
Pulmonary Disease 20 76.24 Quite High
Cancer 4 74.20 Quite High
Gastrointestinal Disease 4 73.24 Quite High
Sprains And Strains 4 72.16 Quite High
Diabetes Mellitus 4 71.76 Quite High
Injury 8 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP activation in HAP might be necessary for bacterial clearance, but unresolved infection might trigger ongoing MMP activation and tissue destruction[26,27].
Positive_regulation (activation) of HAP associated with metalloproteinase, pneumonia and infection
1) Confidence 0.04 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.33 Pain Relevance 0.55
Low MMP increment and activation in HAP-patients with low-risk bacteria might be explained by less virulence of these bacteria.
Positive_regulation (activation) of HAP associated with metalloproteinase and pneumonia
2) Confidence 0.04 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.86 Pain Relevance 0.60
The molar MMP-9/TIMP-1 ratio and the gelatinolytic activity of MMP-9 was increased in HAP patients compared to controls (MMP-9/TIMP-1 ratio 0.43 (± 0.12) vs. 0.04 (± 0.02), p < 0.0001; MMP-9 activity 149 (± 41) vs. 34 (± 11), p = 0.0001).
Positive_regulation (increased) of HAP in molar associated with metalloproteinase and pneumonia
3) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.94 Pain Relevance 0.60
Hartog et al. found increased activated pulmonary MMP in hospital-acquired pneumonia (HAP) with some evidence of increased MMP levels in patients with proven bacterial infection [8].
Positive_regulation (activated) of HAP associated with metalloproteinase, pneumonia and bacterial infection
4) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.94 Pain Relevance 0.77

General Comments

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