INT243073

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2008
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 5
Total Number 22
Disease Relevance 1.47
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsn) extracellular space (Gsn) vesicle-mediated transport (Gsn)
extracellular region (Gsn) cytoskeleton (Gsn) protein complex (Gsn)
Anatomy Link Frequency
vestibular hair cells 3
hair 3
4T1 2
hair cell 1
cochlear duct 1
Gsn (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 36 82.12 Quite High
Mechanotransduction 18 48.56 Quite Low
TRP channel 18 45.76 Quite Low
Inflammation 18 25.80 Quite Low
ketamine 18 5.00 Very Low Very Low Very Low
analgesia 18 5.00 Very Low Very Low Very Low
withdrawal 10 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 126 99.20 Very High Very High Very High
Breast Cancer 14 90.72 High High
Deafness 38 85.84 High High
Adhesions 6 73.20 Quite High
Nephrotic Syndrome 16 70.56 Quite High
Aging 18 68.88 Quite High
Renal Disease 12 60.24 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 56.88 Quite High
Congenital Anomalies 2 39.68 Quite Low
Wound Healing 18 26.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is despite the widespread expression of gelsolin in stereocilia along the length of cochlear duct.
Gene_expression (expression) of gelsolin in cochlear duct
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.26 Pain Relevance 0.04
Gelsolin is detected in OHC where it localizes to the tips of the shorter rows but not to the longest row of stereocilia and the pattern of localisation at the apical hair cell surface is strikingly similar to p55.
Gene_expression (detected) of Gelsolin in hair cell
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Finally, we investigated the expression of gelsolin in the vestibular system and found that gelsolin was absent in vestibular hair cells (Supplementary Information Figure S2).


Spec (investigated) Gene_expression (expression) of gelsolin in vestibular hair cells
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
It is noteworthy that, though the emergence of the mutant phenotype (at P9) overlaps the period in which gelsolin is expressed, stereocilia defects appear relatively late despite a complete absence of gelsolin in the developing hair bundle.
Gene_expression (expressed) of gelsolin in hair
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Stereocilia maturation is considered complete by around P7 [16] and thus gelsolin is present in the stereocilia bundle during the critical period of stereocilia development and elongation.
Gene_expression (present) of gelsolin
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.16 Pain Relevance 0
GST-tagged gelsolin constructs containing either S1 and S2 (P1), S3 and S4 (P2) or S5 and S6 (P3) gelsolin domains were expressed in E. coli K12 ER2508 cells using pGEX-4T1.
Gene_expression (expressed) of gelsolin in 4T1
6) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
SEM analysis of the vestibular hair cells showed no stereocilia abnormality which is supported by the observation that gelsolin is not expressed in vestibular hair cells (Supplementary Information Figure S2).


Neg (not) Gene_expression (expressed) of gelsolin in vestibular hair cells
7) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.09 Pain Relevance 0.04
Finally, we investigated the expression of gelsolin in the vestibular system and found that gelsolin was absent in vestibular hair cells (Supplementary Information Figure S2).


Neg (absent) Gene_expression (absent) of gelsolin in vestibular hair cells
8) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
In both the whirler and shaker2 mutants, expression of gelsolin is considerably reduced at P2 and is ablated from P5, similar to that seen for p55 [11] (Fig. 3).
Gene_expression (expression) of gelsolin
9) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.12 Pain Relevance 0
Gelsolin is confined to the outer hair cells and, like p55, is not expressed in inner hair cells (IHCs).
Neg (not) Gene_expression (expressed) of Gelsolin in inner hair cells
10) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.19 Pain Relevance 0
We show that the actin capping and severing protein, gelsolin, is a part of the whirlin complex.
Gene_expression (capping) of gelsolin
11) Confidence 0.59 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Like p55, gelsolin is ablated in the whirler and shaker2 mutants.
Gene_expression (ablated) of gelsolin
12) Confidence 0.59 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
Epistasis of the whirler and gelsolin mutants
Gene_expression (mutants) of gelsolin
13) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.08 Pain Relevance 0.04
Functional analysis of gelsolin in stereocilia using whirler and shaker2 mutants
Gene_expression (analysis) of gelsolin
14) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
We found that GST fusions with the S1/S2, the S3/S4 and S5/S6 domains of gelsolin pulled down the p55 GUK domain (Fig. 1c).


Gene_expression (fusions) of gelsolin
15) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.06 Pain Relevance 0
We found that GST fusions with the S1/S2, the S3/S4 and S5/S6 domains of gelsolin pulled down the p55 GUK domain (Fig. 1c).


Gene_expression (domains) of gelsolin
16) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0.06 Pain Relevance 0
It is noteworthy that, though the emergence of the mutant phenotype (at P9) overlaps the period in which gelsolin is expressed, stereocilia defects appear relatively late despite a complete absence of gelsolin in the developing hair bundle.
Gene_expression (expressed) of gelsolin in hair
17) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
GST-tagged gelsolin constructs containing either S1 and S2 (P1), S3 and S4 (P2) or S5 and S6 (P3) gelsolin domains were expressed in E. coli K12 ER2508 cells using pGEX-4T1.
Gene_expression (expressed) of gelsolin in 4T1
18) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
While not all of these proteins were specifically shown to be TRPC6 binding proteins in this publication, one of the authors reports that at least eight, Spna2, Spnb2, Myh9, Myh10, Actn1, Acnt4, Dbn1, Gsn, do also specifically co-IP with TRPC6 (W.P.
Gene_expression (eight) of Gsn
19) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.38 Pain Relevance 0
In addition, expression of five (20%) other coregulators (cyclin D1, gelsolin, prohibitin, JMJD1A, and JMJD2C) was significantly, but less than 2-fold, induced by androgens.
Gene_expression (expression) of gelsolin
20) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox