INT24309

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Context Info
Confidence 0.36
First Reported 1988
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.98
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sdhb) mitochondrion (Sdhb) oxidoreductase activity (Sdhb)
Anatomy Link Frequency
brain 1
pole 1
Sdhb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 66 100.00 Very High Very High Very High
Enkephalin 10 99.36 Very High Very High Very High
substance P 8 99.04 Very High Very High Very High
Dopamine 3 96.28 Very High Very High Very High
anesthesia 3 94.80 High High
IPN 5 93.96 High High
Disease Link Frequency Relevance Heat
Immunization 21 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male Wistar rats received two immunizations with IP18-KLH in Freund's incomplete adjuvant, 21 days apart, and experiments were performed 7-11 days post-immunization under chloral hydrate anesthesia.
IP18-KLH Binding (immunizations) of associated with anesthesia and immunization
1) Confidence 0.36 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15375641 Disease Relevance 0.31 Pain Relevance 0.71
In conclusion, the attenuation of the reinforcing effect of nicotine after immunization with IP18-KLH, shown previously, is indeed associated with an altered distribution of nicotine.
IP18-KLH Binding (immunization) of associated with nicotine and immunization
2) Confidence 0.36 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15375641 Disease Relevance 0.50 Pain Relevance 0.72
We have previously shown that active immunization with the nicotine immunoconjugate IP18-KLH attenuates the reinforcing effects of nicotine, i.e., suppresses the nicotine-induced brain dopamine release and prevents reinstatement of the nicotine-seeking behavior in rats.
IP18-KLH Binding (immunization) of in brain associated with dopamine, nicotine and immunization
3) Confidence 0.31 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15375641 Disease Relevance 0.17 Pain Relevance 0.43
As the descriptions of the IP-RL, IP-L, and IP-CL were inconsistent with previous reports, they were reevaluated; the IP-RL was proposed as the region situated in the lateral portion at rostral levels and characterized by the lack of ENK and SP immunoreactive structures, the IP-L as the region situated throughout the rostrocaudal extent in the lateral portion of the IPN and containing the highest density of SP immunoreactive fibers but no ENK immunoreactive fibers, and the IP-CL as the region situated just laterocaudal to the IP-L in the caudal pole of the IPN and containing ENK immunoreactive cells and fibers but no SP immunoreactive structures.
IP-RL Binding (characterized) of in pole associated with ipn, enkephalin and substance p
4) Confidence 0.14 Published 1988 Journal J. Comp. Neurol. Section Abstract Doc Link 2454248 Disease Relevance 0 Pain Relevance 1.17

General Comments

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