INT2431

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2011
Negated 14
Speculated 7
Reported most in Abstract
Documents 275
Total Number 282
Disease Relevance 211.99
Pain Relevance 78.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) aging (Mpo)
Anatomy Link Frequency
plasma 21
neutrophil 19
liver 10
colon 9
leukocyte 8
Mpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 103 100.00 Very High Very High Very High
Raphe magnus 84 100.00 Very High Very High Very High
chemokine 47 100.00 Very High Very High Very High
cINOD 186 99.92 Very High Very High Very High
cytokine 202 99.90 Very High Very High Very High
fibrosis 9 99.88 Very High Very High Very High
diclofenac 19 99.84 Very High Very High Very High
Inflammatory response 149 99.82 Very High Very High Very High
Inflammatory mediators 67 99.80 Very High Very High Very High
Inflammation 956 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1465 100.00 Very High Very High Very High
Stress 498 100.00 Very High Very High Very High
Apoptosis 118 100.00 Very High Very High Very High
Necrosis 75 100.00 Very High Very High Very High
Pressure And Volume Under Development 65 100.00 Very High Very High Very High
Cancer 58 100.00 Very High Very High Very High
Ulcers 47 100.00 Very High Very High Very High
Aids-related Complex 46 100.00 Very High Very High Very High
Frailty 11 99.92 Very High Very High Very High
Injury 936 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed a time dependent increase in MPO activity.
Positive_regulation (increase) of MPO associated with urological neuroanatomy
1) Confidence 0.70 Published 1990 Journal Int J Microcirc Clin Exp Section Abstract Doc Link 2158941 Disease Relevance 1.17 Pain Relevance 0.33
RESULTS: At 2 days post-induction of colitis, the colon showed characteristic inflammatory changes in histology and 8-fold increase in MPO activity.
Positive_regulation (increase) of MPO in colon
2) Confidence 0.70 Published 2003 Journal World J. Gastroenterol. Section Body Doc Link 14669335 Disease Relevance 0.15 Pain Relevance 0
No increase in the MPO levels was observed after 1.5 hours of ischemia followed by 12 hours of reperfusion.
Neg (No) Positive_regulation (increase) of MPO associated with ischemia and urological neuroanatomy
3) Confidence 0.70 Published 1990 Journal Int J Microcirc Clin Exp Section Abstract Doc Link 2158941 Disease Relevance 0.91 Pain Relevance 0.32
Gastric LPO and MPO activity that were increased significantly by ASA were decreased after treatment with omeprazole, famotidine, and melatonin.
Positive_regulation (increased) of MPO associated with aspirin and urological neuroanatomy
4) Confidence 0.70 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11281181 Disease Relevance 0.46 Pain Relevance 0.43
Likewise, when compared with sham operated controls, MPO activity was found to be increased in the ligated hindpaw (Optic Density 0.15 vs. 0.89; p < 0.001).
Positive_regulation (increased) of MPO in Optic associated with urological neuroanatomy
5) Confidence 0.70 Published 1998 Journal Neurol. Res. Section Abstract Doc Link 9471102 Disease Relevance 0.81 Pain Relevance 0.64
The hydroalcoholic extract (200 mg/kg) substantially reduced MPO activity (P < 0.05), which was increased in the control group.
Positive_regulation (increased) of MPO associated with urological neuroanatomy
6) Confidence 0.70 Published 2001 Journal J Ethnopharmacol Section Abstract Doc Link 11297854 Disease Relevance 0.89 Pain Relevance 0.32
The increase in MPO activity occurred only in the region previously exposed to the hapten.
Positive_regulation (increase) of MPO associated with urological neuroanatomy
7) Confidence 0.70 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7631788 Disease Relevance 1.64 Pain Relevance 0.38
We found that (1) capsaicin denervation blocked stress-induced increase of visceral sensitivity, while doxantrazole presented a partial blocking; (2) capsaicin denervation blocked stress-induced enhancement of the proximity of mast cell-nerve fiber-blood vessels and blood vessel damage, while doxantrazole showed no effects on these; (3) doxantrazole blocked stress-induced increases of the MPO activity, the number and the degranulation of mast cells in the colon; (4) sensory denervation and doxantrazole had no effects on stress-induced behavioral inhibition.
Positive_regulation (increases) of MPO in visceral associated with stress, qutenza and urological neuroanatomy
8) Confidence 0.70 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 19051028 Disease Relevance 0.87 Pain Relevance 0.46
Caerulein significantly increased MPO activity and wet-to-dry weight ratio, produced histological evidence of edematous pancreatitis, induced plasma extravasation, and caused hyperamylasemia.
Positive_regulation (increased) of MPO in plasma associated with hyperamylasemia, pancreatitis and urological neuroanatomy
9) Confidence 0.70 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12223354 Disease Relevance 1.33 Pain Relevance 0.33
RESULTS: Infection with N. brasiliensis resulted in an increase of myeloperoxidase (MPO) activity and mast cell numbers at day 12 postinfection; MPO returned to preinfection levels by day 35 while mast cell numbers remained elevated at that time.
Positive_regulation (increase) of myeloperoxidase in mast cell
10) Confidence 0.70 Published 2000 Journal Neuroimmunomodulation Section Body Doc Link 11251391 Disease Relevance 0.08 Pain Relevance 0
RESULTS: Infection with N. brasiliensis resulted in an increase of myeloperoxidase (MPO) activity and mast cell numbers at day 12 postinfection; MPO returned to preinfection levels by day 35 while mast cell numbers remained elevated at that time.
Positive_regulation (increase) of MPO in mast cell
11) Confidence 0.70 Published 2000 Journal Neuroimmunomodulation Section Body Doc Link 11251391 Disease Relevance 0.08 Pain Relevance 0
In capsaicin-treated infected rats, the MPO increase at day 12 was augmented, and MPO was still not returned to preinfection values by day 35; in contrast, the increase of mast cell numbers at days 12 and 35 was not modified by afferent nerve depletion.
Positive_regulation (increase) of MPO in nerve
12) Confidence 0.70 Published 2000 Journal Neuroimmunomodulation Section Body Doc Link 11251391 Disease Relevance 0.06 Pain Relevance 0
In ketotifen-treated infected rats, the increase of MPO at day 12 was less pronounced, but MPO activity remained elevated and mast cell numbers were increased at day 35.
Positive_regulation (elevated) of MPO in mast cell
13) Confidence 0.70 Published 2000 Journal Neuroimmunomodulation Section Body Doc Link 11251391 Disease Relevance 0.07 Pain Relevance 0
Likewise, it could be expected that systemic treatment using drugs of established mechanisms of action, such as celecoxib and morphine, a selective nonsteroidal anti-inflammatory drug [23], and a classical opioid agonist, respectively, would also reverse the detected increase in MPO activity.
Positive_regulation (increase) of MPO associated with mu agonist, inflammation, cinod, urological neuroanatomy and morphine
14) Confidence 0.70 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2804053 Disease Relevance 1.01 Pain Relevance 0.59
Rosiglitazone also attenuated tibial and sural nerve transection-induced increase in oxidative stress, myeloperoxidase activity and calcium levels.
Positive_regulation (increase) of myeloperoxidase in nerve associated with stress
15) Confidence 0.70 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 19429470 Disease Relevance 0.82 Pain Relevance 0.76
In the sedentary colitis group, macroscopic and microscopic damage scores, malondialdehyde level and myeloperoxidase activity were increased when compared to the control group (P < 0.01-0.001), while exercise prior to colitis reduced all the measurements with respect to sedentary colitis group (P < 0.05-0.001).
Positive_regulation (increased) of myeloperoxidase associated with colitis
16) Confidence 0.70 Published 2006 Journal Exp. Physiol. Section Abstract Doc Link 16763006 Disease Relevance 1.19 Pain Relevance 0.15
Similar results were obtained for mast cells and apoptosis in capsaicin irradiated rats as compared to capsaicin sham-irradiated rats, while MPO activity was significantly increased and CGRP concentration in jejunal mucosa significantly decreased from the first day in these rats in comparison with capsaicin sham-irradiated rats.
Positive_regulation (increased) of MPO in mast cells
17) Confidence 0.70 Published 2001 Journal Int. J. Radiat. Biol. Section Body Doc Link 11258849 Disease Relevance 0 Pain Relevance 0
RESULTS: In vehicle irradiated rats, CGRP was significantly increased from the first day after irradiation in jejunal mucosa; MPO activity increased in both segments at day 3 but not at day 1 after irradiation; the number of detectable mucosal mast cells dropped to nearly zero on days 1 and 3, while the apoptotic cells in the intestinal mucosa were significantly increased at day 1.
Neg (not) Positive_regulation (increased) of MPO in apoptotic cells
18) Confidence 0.70 Published 2001 Journal Int. J. Radiat. Biol. Section Body Doc Link 11258849 Disease Relevance 0 Pain Relevance 0
Our study showed that cold-restraint stress for 3 h induced hemorrhagic lesions and increased myeloperoxidase activity in the gastric mucosa.
Positive_regulation (induced) of myeloperoxidase associated with stress
19) Confidence 0.70 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12559379 Disease Relevance 1.31 Pain Relevance 0.52
Our study showed that cold-restraint stress for 3 h induced hemorrhagic lesions and increased myeloperoxidase activity in the gastric mucosa.
Positive_regulation (increased) of myeloperoxidase associated with stress
20) Confidence 0.70 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12559379 Disease Relevance 1.30 Pain Relevance 0.52

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